GENDER-RELATED CORRELATION OF PAIN SENSATION, MOR LEVEL AND SOME HOSTILITY INDICES.

The purpose of given study was to elucidate the relationship among heat, cold, mechanical pain sensation degrees and MOR level in almost healthy males and females - both if follicular and luteal phases of the OMC; also, to investigate gender-related correlation between all above parameters and some hostility indices. The study revealed differences in MOR level according to gender and phases of the OMC - insignificantly higher MOR level in luteal phase of the OMC compared with follicular in females, results of males are significantly lower compared of females in both phases. As gender-related so phase-dependent differences of MOR level negatively correlate with pain sensation indices: heat, cold and mechanical pain thresholds, mechanical pain tolerance.

SEX DIFFERENCES IN RESPONSE TO EXPERIMENTALLY INDUCED PAIN.

The purpose of this study was to elucidate the relationship between thermal and mechanical sensation, as well as pain thresholds degrees and the dynamics of the TRPV1 level in almost healthy young males and females in the follicular and luteal phases of the OMC. We found gender differences for some pain sensation indices, taking into account OMC phases of females. Mechanical pain tolerance and heat pain thresholds were significantly higher in males compared with females in both phases of the OMC, also, mechanical pain, mechanical pressure, cold pain and heat sensation thresholds were insignificantly higher in males compared with females in follicular phase of the OMC and significantly higher - in luteal phase of the OMC.

THE RELATIONSHIP BETWEEN THERMAL PAIN SENSATION, FREE TESTOSTERONE, TRPV1, MOR LEVELS AND VARIOUS DEGREES OF HOSTILITY IN YOUNG HEALTHY MALES.

Large number of studies consider gonadal hormones as factors influencing pain perception by changing the activity of nociceptive and antinociceptive systems. Recent studies indicate that testosterone, along with some other gonadal hormones, plays a key role in the regulation of TRPV1 and MOR expression. In addition, some works focus on the relationship between pain sensation and hostility indices, as well as their interaction with gonadal hormones.