Publications by authors named "Chaithanya Lakshmi"
Cancer Res Treat
April 2023
Article Synopsis
- * Researchers explored the use of small interfering RNAs (siRNAs) targeting the BRD4-NUTM1 fusion (B4N), the most prevalent type in NC, to assess their potential as a treatment option and evaluated patient blood samples for treatment response.
- * The study found that B4N-specific siRNA effectively inhibited the fusion transcript and protein, reducing cell growth and tumor size, while levels of the fusion transcript in patient samples correlated with treatment responsiveness, indicating a pathway for precision medicine in managing NC.
