Polystyrene nanoplastics: optimized removal using magnetic nano-adsorbent and toxicity assessment in zebrafish embryos.

Purpose: The presence of microplastics (MPs) and nanoplastics (NPs) in aquatic ecosystems has raised serious environmental and health concerns. Polystyrene is one of the most abundant plastic polymers found in the environment. Polystyrene MPs/NPs have harmful implications for human health and their removal from the environment has become a serious challenge.

Efficient femtosecond optical parametric generation in group-velocity-matched MgO:PPLN at 10 MHz.

We report on efficient single-pass optical parametric generation (OPG) of broadband femtosecond pulses in the mid-infrared at 10 MHz by exploiting group-velocity-matched interaction in a 42-mm-long MgO:PPLN crystal. Using a microchip-started femtosecond amplified Mamyshev oscillator at 1064 nm as the pump, the OPG source can provide tunable femtosecond pulses across 1516-1566 nm in the signal and 3318-3568 nm in the idler, with slope efficiencies of ∼93% and ∼41%, respectively. For 650 mW of average input pump power, signal powers of up to 283 mW at 1524 nm are generated, with more than 200 mW over the entire tuning range.

Kisspeptin promotes follicular development through its effects on modulation of P450 aromatase expression and steroidogenesis in sheep ovarian follicles.

The present study was conducted to ascertain whether the role of kisspeptin in promoting in vitro development of preantral follicles was through the regulation of P450 aromatase gene expression and steroidogenesis in sheep. Accordingly, the cumulus cells and oocytes were collected from different development stages of preantral follicles grown in vivo and cultured in vitro in TCM199B (Group I), TCM199B + KP (10 μg/mL) (Group II) and Standard medium + KP (10 μg/mL). To measure the steroid (Estradiol-17β; E and Progesterone; P ) synthesis through ELISA, spent culture medium was collected separately from the same in vitro groups.

Up-converted photorefractive optical transient detection with femtosecond laser pulses.

We report on experimental demonstration of optical transient detection (OTD) based on photorefractive two-wave mixing of femtosecond pulses. The demonstrated technique also combines nonlinear-crystal-based OTD with up-conversion from infrared into the visible range. The approach enables measurement of phase changes of a dynamic signal in the infrared using GaP- or Si-based detectors while suppressing stationary background.

Assessment of Understandability and Actionability of YouTube Videos on Hemolytic Disease of the Newborn.

Introduction With revolutions in Information Technology, information and misinformation are easier to be found online. YouTube is the largest and most commonly searched video content website in the world. It is assumed that, due to the coronavirus pandemic, most patients try to know about diseases through the internet and reduce the number of hospital exposures unless otherwise.

Understandability and Actionability of Available Video Information on YouTube Regarding Hemophilia: A Cross-Sectional Study.

Introduction With the advent of revolutionary information technology, most general medical information can be accessed by the community at large. However, the factual nature of information, its understandability, and actionability of diseases like Hemophilia are unknown to the general population. Hence the present study has been envisaged to assess the understandability and actionability of available video information on YouTube about Hemophilia.

Yb-fiber-pumped high-average-power picosecond optical parametric oscillator tunable across 1.3-1.5 μm.

We report the generation of high-repetition-rate picosecond pulses in the 1.3-1.5 µm spectral range by internal second harmonic generation (SHG) of an idler-resonant optical parametric oscillator (OPO) based on MgO-doped periodically-poled LiNbO (MgO:PPLN), synchronously pumped by ∼20 ps pulses at 80 MHz using an Yb-fiber laser at 1.

Usefulness of Cat Score in Patients with Stable Copd and Acute Exacerbation of Copd and it's Co-Relation with PFT.

COPD was reported to be the 6th leading cause of death worldwide in the year 1990 and 4th in 2000. The CAT i.e.

Fasting Lipid Profile in Type 2 Diabetes- Necessity or Redundancy.

Unlabelled: Diabetes mellitus is characterized not only by alteration in glucose insulin axis but marked features described as the diabetic dyslipidemia. The increased lipid level and total cholesterol synthesis during hyperglycemia may contribute to the acceleration of atherosclerosis in diabetes mellitus. Majority of guidelines currently recommend a fasting serum lipid for achieving consistency.

Tunable, high-power, high-order optical vortex beam generation in the mid-infrared.

We report the generation of tunable high-order optical vortices in the mid-infrared (mid-IR) using a picosecond optical parametric oscillator (OPO). The OPO is based on MgO:PPLN as the nonlinear gain medium and synchronously pumped by a mode-locked Yb-fiber laser at 1064 nm. Using a singly-resonant oscillator configuration for the OPO, we have achieved direct transfer of pump optical vortices to the non-resonant idler beam, with the resonant signal in the Gaussian cavity mode.

Broadly tunable, intracavity injection-seeded, hybrid optical parametric oscillator.

We report a novel, to the best of our knowledge, approach for injection seeding of pulsed optical parametric oscillators (OPOs), which can provide spectral control over the full tuning range. Bandwidth reduction down to single-mode operation is realized across the pulsed tuning range by deploying a hybrid design, where a continuous-wave (cw) OPO injection seeds the pulsed OPO in a single composite cavity. By exploiting two identical MgO-doped periodically poled lithium niobate crystals, the hybrid OPO provides signal pulses with a single-frequency linewidth as narrow as 7.

Tunable vortex beam generation using an optical parametric oscillator with an antiresonant-ring interferometer.

We report a high-average-power picosecond optical vortex source tunable in the near-infrared, using an antiresonant-ring (ARR) interferometer internal to an optical parametric oscillator (OPO) in combination with an external cylindrical lens for astigmatic mode conversion. The ARR OPO is tunable in the signal across 1457-1647 nm with a vortex intensity profile and up to 1 W of average power at 1602 nm. The corresponding idler is tunable over 3006-3945 nm in a Gaussian intensity profile with as much as 1.

Performance studies of high-average-power picosecond optical parametric generation and amplification in MgO:PPLN at 80 MHz.

We report on performance studies of high-average-power single-pass picosecond optical parametric generation (OPG) and amplification (OPA) tunable near 2 µm in MgO:PPLN pumped by an Yb-fiber laser at 1.064 µm and 80 MHz pulse repetition rate. The simple setup based on two identical crystals, and without the need for an intermediate delay line for synchronization, delivers up to 6.

Green-pumped continuous-wave parametric oscillator based on fanout-grating MgO:PPLN: publisher's note.

This publisher's note contains corrections to Opt. Lett.45, 6486 (2020)OPLEDP0146-959210.

Green-pumped continuous-wave parametric oscillator based on fanout-grating MgO:PPLN.

We report the first green-pumped continuous-wave (cw) optical parametric oscillator (OPO) based on MgO:PPLN in a fanout grating design. Pumped by a single-frequency cw laser at 532 nm, the OPO provides tunable radiation across 813-1032 nm in the signal and 1098-1539 nm in the idler by simple mechanical translation at a fixed temperature of 55°C. By deploying a 25-mm-long crystal to minimize thermal effects and using output coupling for the signal wave, we generate a total output power of up to 714 mW at 30% extraction efficiency in excellent Gaussian beam quality with <1.

Fiber-laser-pumped high-repetition-rate picosecond optical parametric generation and amplification in MgO:PPLN.

We report the generation of tunable high-repetition-rate picosecond pulses in the near-infrared at high average power with record conversion efficiency using single-pass optical parametric generation (OPG) and amplification (OPA) in MgO:PPLN, for the first time, to the best of our knowledge. By deploying a mode-locked Yb-fiber laser at 1064 nm providing 21 ps pump pulses at 80 MHz, and a cascade of two 50-mm-long MgO:PPLN crystals, we generate up to 8.3 W of total average output power at a conversion efficiency of 59% over a tunable range of 513 nm, across 1902-2415 nm, with a record threshold as low as 600 mW (7.

Multi-structured-beam optical parametric oscillator.

Structured beams, conventionally generated through the spatial mode conversion of the Gaussian laser beams, have attracted great interest in recent years. Optical parametric oscillators (OPOs) have demonstrated the potential for the generation of tunable structured beams directly from an input pump source. However, to date, a particular OPO design has been shown to produce such beams only in a specific configuration and different spatial structured beams require different system architectures.

Phase-locked picosecond optical parametric oscillator.

We report a degenerate self-phase-locked picosecond optical parametric oscillator (OPO) synchronously pumped by a mode-locked Yb-fiber laser at 1064 nm, delivering broadband output near 2 µm with 2.8 W of average power at ∼80 repetition rate. By exploiting a 50-mm-long MgO:PPLN crystal providing high gain and low group velocity dispersion under type-0 (→) phase matching, the OPO generates a phase-locked degenerate output spectrum with a bandwidth of ∼202 centered at 2128 nm in pulses of ∼21 duration with excellent passive long-term power and spectral stability in high spatial beam quality.

Substantial tumor regression in prostate cancer patient with extensive skeletal metastases upon Immunotherapy (APCEDEN): A case report.

Rationale: Prostate cancer along with colorectal and lung cancers accounts for 42% of cancer cases in men globally. It is the first cancer indication for which the use of active immunotherapy, Sipuleucel-T (Provenge) was granted by the FDA in 2010. This study presents a case of prostate carcinoma and the tumour remission observed after administration of a personalised Dendritic cell vaccine (APCEDEN).

Substantial remission of prostate adenocarcinoma with dendritic cell therapy APCEDEN in combination with chemotherapy.

Of the most prevalent solid tumors with advanced disease, prostate and ovarian cancer and non-small cell lung carcinoma have the fewest therapeutic options. Herein, we report the case of a 63-year-old male with metastatic prostate adenocarcinoma showing substantial remission post-administration of personalized dendritic cell-based vaccine APCEDEN in combination with chemotherapeutic drug Mitoxantrone. Therapeutic response displayed an interesting clinical correlation validated by PET scan images showing decreased fluorodeoxyglucose (FDG) avidity in the prostate gland, reduced skeletal metastases further established by the drop in serum Prostate Specific Antigen (PSA) levels and expression of immune assessment markers (IFN-γ, Tregs, neutrophil lymphocyte ratio and platelet lymphocyte ratio).

Green-pumped optical parametric oscillator based on fan-out grating periodically-poled MgO-doped congruent LiTaO.

We report a green-pumped optical parametric oscillator (OPO) based on periodically poled MgO-doped congruent lithium tantalate (MgO:cPPLT). Pumped at 532 nm by a frequency-doubled Q-switched Nd:YAG laser, and using a fan-out grating structure, the singly-resonant OPO provides continuous tuning across 689-1025 nm in the signal and 1106-2336 nm in the idler at room temperature by simple mechanical translation of the crystal. The tuning range can be further extended to 677 nm and 2479 nm in the signal and idler, respectively, by temperature tuning the crystal to 200°C.

Tunable ultraviolet vortex source based on a continuous-wave optical parametric oscillator.

We report a continuous-wave (cw) optical parametric oscillator (OPO) generating optical vortices tunable in the ultraviolet (UV). Based on MgO:sPPLT as the nonlinear crystal, the singly resonant OPO is pumped by a cw vortex beam in the green, and deploying intracavity sum-frequency generation (SFG) between the undepleted pump and the Gaussian resonant signal in the crystal of BiBO, it can generate optical vortices of order, l=1 and 2, tunable across 332-344 nm in the UV with a maximum power of 12 mW. Due to conservation of orbital angular momentum in the parametric process, the OPO also produces a non-resonant idler output beam in a vortex spatial profile of order l=1 and 2, identical to the pump vortex, with the signal beam in Gaussian distribution.

Femtosecond optical parametric oscillator continuously tunable across 3.6-8 μm based on orientation-patterned gallium phosphide.

We report a synchronously-pumped femtosecond optical parametric oscillator (OPO) based on orientation-patterned gallium phosphide (OP-GaP), providing continuously tunable mid-infrared (mid-IR) idler radiation across 3570-7892 nm (2801-1267  cm), by exploiting pump wavelength tuning. We generate up to 54 mW of output average power at 80 MHz, and quantum conversion efficiencies up to 28.9% are achieved by use of synchronized pump retroreflection.