DeepFocus: a transnasal approach for optimized deep brain stimulation of reward circuit nodes.

Transcranial electrical stimulation (TES) is an effective technique to modulate brain activity and treat diseases. However, TES is primarily used to stimulate superficial brain regions and is unable to reach deeper targets. The spread of injected currents in the head is affected by volume conduction and the additional spreading of currents as they move through head layers with different conductivities, as is discussed in Forssell(2021046042).

Cell-specific effects of temporal interference stimulation on cortical function.

Temporal interference (TI) stimulation is a popular non-invasive neurostimulation technique that utilizes the following salient neural behavior: pure sinusoid (generated in off-target brain regions) appears to cause no stimulation, whereas modulated sinusoid (generated in target brain regions) does. To understand its effects and mechanisms, we examine responses of different cell types, excitatory pyramidal (Pyr) and inhibitory parvalbumin-expressing (PV) neurons, to pure and modulated sinusoids, in intact network as well as in isolation. In intact network, we present data showing that PV neurons are much less likely than Pyr neurons to exhibit TI stimulation.

PATHFINDER: Designing Stimulus for Neuromodulation Through Data-Driven Inverse Estimation of Non-Linear Functions.

Objective: Using data-driven methods to design stimuli (e.g., electrical currents) which evoke desired neural responses in different neuron-types for applications in treating neural disorders.

Focused Epicranial Brain Stimulation by Spatial Sculpting of Pulsed Electric Fields Using High Density Electrode Arrays.

Transcranial electrical neuromodulation of the central nervous system is used as a non-invasive method to induce neural and behavioral responses, yet targeted non-invasive electrical stimulation of the brain with high spatial resolution remains elusive. This work demonstrates a focused, steerable, high-density epicranial current stimulation (HD-ECS) approach to evoke neural activity. Custom-designed high-density (HD) flexible surface electrode arrays are employed to apply high-resolution pulsed electric currents through skull to achieve localized stimulation of the intact mouse brain.

HingePlace: Focused transcranial electrical current stimulation that allows subthreshold fields outside the stimulation target.

Transcranial Electrical Stimulation (TES) is a promising tool for treating many neurological disorders, but it classically results in diffused stimulation. Many optimization algorithms have been proposed for focusing TES, commonly by creating multi-electrode arrangements and choosing current amplitudes such that the resulting current fields in the brain are focused in the target region, and are as small as possible outside the target region. Consequently, it is likely that such optimization does not harness the non-linear nature of neural dynamics, particularly their thresholding phenomenon, i.

Effect of skull thickness and conductivity on current propagation for noninvasively injected currents.

When currents are injected into the scalp, e.g. during transcranial current stimulation, the resulting currents generated in the brain are substantially affected by the changes in conductivity and geometry of intermediate tissue.