Publications by authors named "Chaitali Mallick"
Tuberculosis is a disease caused by Mycobacterium tuberculosis (Mtb), affecting millions of people worldwide. The emergence of drug resistance is a major problem in the successful treatment of tuberculosis. Due to the commencement of MDR-TB (multi-drug resistance) and XDR-TB (extensively drug resistance), there is a crucial need for the development of novel anti-tubercular agents with improved characteristics such as low toxicity, enhanced inhibitory activity and short duration of treatment.
View Article and Find Full Text PDFSchizophrenia is a chronic neuropsychiatric disorder that affects nearly 1% of the global population. There are various anti-psychotic drugs available for the treatment of schizophrenia, but they have certain side effects; therefore, there is a need to explore and develop novel potential lead compounds against schizophrenia. The currently available drugs e.
View Article and Find Full Text PDFArticle Synopsis
- Diabetes mellitus is a growing global health issue, with significant prevalence rates in developed countries like the USA, China, and India, highlighting a need for new treatments as the number of diabetic patients continues to rise.
- The sodium-glucose co-transporter 2 (SGLT2) has emerged as a key target for Type 2 diabetes treatment, due to its unique mechanism of action that doesn’t involve insulin signaling.
- Various SGLT2 inhibitors, including dapagliflozin and its analogues, are currently being explored in clinical trials, with ongoing research focused on their chemical structures and effectiveness in managing diabetes.