Publications by authors named "Chairuddin P Lubis"
Background: We assessed the efficacy of artemisinin-based combination therapies for treatment of uncomplicated malaria, with or without co-infecting spp., in Sumatera, Indonesia.
Methods: Febrile patients aged >6 months with uncomplicated were randomized to receive dihydroartemisinin-piperaquine or artemether-lumefantrine, plus single-dose primaquine, and were followed for 42 days.
Artemisinin-based combination therapy (ACT) is the first-line antimalarial regimen in Indonesia. Susceptibility of to artemisinin is falling in the Greater Mekong subregion, but it is not known whether the efficacy of current combinations is also threatened in nearby Sumatera. We evaluated the genetic loci , and , considered to be under selection by artemisinin combination therapy, among 404 infections identified by PCR detection in a cross-sectional survey of 3,731 residents of three regencies.
View Article and Find Full Text PDFBackground: As Indonesia works toward the goal of malaria elimination, information is lacking on malaria epidemiology from some western provinces. As a basis for studies of antimalarial efficacy, we set out to survey parasite carriage in 3 communities in North Sumatera Province.
Methods: A combination of active and passive detection of infection was carried out among communities in Batubara, Langkat, and South Nias regencies.
Article Synopsis
- The study aimed to evaluate the effectiveness of albendazole and mebendazole in treating Ascaris lumbricoides infections among primary school children in North-Western Indonesia.
- A total of 229 infected children were given either 400 mg of albendazole or 500 mg of mebendazole, and stool samples were analyzed for cure and egg reduction rates after one week.
- Results indicated that while both medications were effective, with no drug resistance detected, albendazole was slightly more effective in sterilizing A. lumbricoides eggs compared to mebendazole.