Rapid Arc-SBRT: Non-Invasive Immune Adjuvant for Advanced Stage Non-Small Cell Lung Carcinoma.

In conjunction with radio-chemotherapy, pulmonary resection is recommended for early-stage nonsmall- cell lung carcinoma but not for advanced-stage NSCLC patients having high-grade metastatic lesions. In these cases, the rapid Arc-Stereotactic body radiotherapy (Ra-SBRT) technique offers a therapeutic advantage by delivering focal irradiation to metastatic lung lesions and reduces the bystander toxicity to normal tissues. We have previously demonstrated that Ra-SBRT ablates metastatic lesions and induces tumor immune rejection of metastatic tumors by promoting in situ programming of M2 TAM towards M1-TAM and infiltration of Siglec-8+ Eosinophils.

Evaluation of AAA and XVMC Algorithms for Dose Calculation in Lung Equivalent Heterogeneity in Photon Fields: A Comparison of Calculated Results with Measurements.

Aims: The aims of the present work are (1) to evaluate dose calculation accuracy of two commonly used algorithms for 15 MV small photon fields in a medium encompassing heterogeneity and (2) to compare them with measured results obtained from gafchromic film EBT2.

Materials And Methods: Authors employed kailwood (Pinus Wallichiana) to mimic lung. Briefly, seven Kailwood plates, each measuring 25x25 cm of varying thicknesses totaling 13 cm equivalent to the mean thickness of an adult human lung, were sandwiched between 5 cm tissue equivalent material from top and 10 cm below.

Radiobiological analysis of stereotactic body radiation therapy for an evidence-based planning target volume of the lung using multiphase CT images obtained with a pneumatic abdominal compression apparatus: a case study.

This study evaluated the efficiency of stereotactic body radiation therapy of lung (SBRT-Lung) in generating a treatment volume using conventional multiple-phase three-dimensional computed tomography (3D-CT) of a patient immobilized with pneumatic abdominal compression. The institutional protocol for SBRT-Lung using the RapidArc technique relied on a planning target volume (PTV) delineated using 3D-CT and accounted for linear and angular displacement of the tumor during respiratory movements. The efficiency of the institutional protocol was compared with that of a conventional method for PTV delineation based on radiobiological estimates, such as tumor control probability (TCP) and normal tissue complication probability (NTCP), evaluated using dose-volume parameters.

Evaluation of dose perturbation at the interface of two different density medium using GAFCHROMIC film EBT2 and Monte Carlo code EGSnrc for Co-60 beam.

Introduction: Accurate dosimetry at the interface of two different density medium (e.g., air cavity in the head and neck cancers and lungs in thoracic region) is a major cause of concern in external beam radiation therapy.