Publications by authors named "Chairini Cassia Thome"
Article Synopsis
- Metabotropic glutamate receptors (mGluR) are key in maintaining brain cell balance but also play a role in cancers, especially aggressive brain tumors like glioblastomas (GBM).
- Recent studies show that blocking mGluR1 and mGluR3 can reduce cancer cell growth and movement, making them potential targets for therapy.
- Clinical trials are underway to explore the use of mGluR antagonists as adjuvant treatments, with early findings suggesting they could enhance the effectiveness of existing cancer drugs like temozolomide.
Several researchers have recently used C6 cells to evaluate functional properties of high-affinity glutamate transporters. However, it has been demonstrated that this lineage suffers several morphological and biochemical alterations according to the number of passages in culture. Currently, there are no reports showing whether functional properties of high-affinity glutamate transporters comply with these sub culturing-dependent modifications.
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