Secretory breast carcinoma (SBC) is a rare breast cancer subtype, histologically, defined by abundant eosinophilic secretions with a triple-negative staining on immunohistochemistry. The diagnosis is made histologically and often requires complementary methods such as immunohistochemical studies and fluorescence in situ hybridization (FISH). Surgery, whether conservative or radical, is the preferred treatment.
View Article and Find Full Text PDFExtraskeletal myxoid chondrosarcoma is a rare mesenchymal neoplasm of uncertain differentiation, characterized morphologically by abundant myxoid stroma, a multinodular growth pattern, and uniform cells arranged in strands, clusters, and reticular networks. It usually occurs in adults in the fifth decade, most often in the deep soft tissues of the proximal extremities. The molecular hallmark of this tumor, present in over 90% of cases, is the fusion of NR4A3 with EWSR1 at 22q12.
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