Publications by authors named "Chaimaa Zerrad"
Article Synopsis
- The study investigates how genetic variations in the IFIH1 gene relate to COVID-19 susceptibility and severity among Moroccans, highlighting the importance of genetic factors in immune response to the virus.
- Results showed that the TT genotype of the rs1990760 variant is linked to higher susceptibility to COVID-19, while the CT genotype appears to offer protective benefits against both infection and severe disease.
- No significant association was found with another variant, rs3747517, indicating that not all genetic factors play a role in COVID-19 outcomes.
Background: Nucleotide-binding oligomerization domain 1 (NOD1) and NOD2 are involved in carcinogenic processes by recognizing bacterial cell wall components and triggering inflammation. This study explored the association between genetic variations in NOD1 and NOD2 and susceptibility to hepatocellular carcinoma (HCC) and its progression in a Moroccan population.
Methods: Genotyping of NOD1 rs2075820 (C>T) and NOD2 rs718226 (A>G) was performed using the TaqMan allelic discrimination assay in 467 Moroccan individuals.
Article Synopsis
- Chronic inflammation caused by hepatitis B (HBV) and C (HCV) increases interleukin 6 (IL-6) levels, which can lead to liver damage and increase the risk of developing hepatocellular carcinoma (HCC).
- A study with 314 participants, including 157 HCC patients, found significantly higher IL-6 levels in HCC patients compared to controls, especially in those with metabolic liver disease.
- Despite higher IL-6 levels in HCC patients, genetic variants rs1800795 and rs1800797 of the IL-6 gene did not show a significant association with the risk of developing HCC.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a primary liver cancer, and the study focuses on the role of the PPARGC1A gene in HCC risk among Moroccans.* -
- Researchers found that individuals with certain genetic variations (GA/AA) of the PPARGC1A gene had a significantly higher risk of developing HCC compared to those with the GG variant.* -
- While one genetic variant (rs8192678) showed a strong association with HCC risk, another variant (rs12640088) did not, highlighting the potential for using rs8192678 as a marker for liver cancer prognosis.*
Association between and genetic variants and the risk of hepatocellular carcinoma in Moroccan population.
Nucleosides Nucleotides Nucleic Acids
November 2023
Hepatocellular carcinoma (HCC) is the fifth most common human malignancy and the fourth most frequent cause of cancer-related deaths worldwide. Toll-like receptors (TLRs), are known to play a key role in hepatocarcinogenesis through induction of inflammation. We aimed to investigate the association between rs3804099, rs4986790, rs4986791, and rs11536889 and 5 rs5744174 and HCC risk in a total of 306 Moroccan subjects, including 152 HCC patient and 154 controls using a TaqMan allelic discrimination assay.
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