A Comparative Analysis on Indoor and Outdoor PM and Their Hourly Associations with Acute Respiratory Inflammation Among College Students in Lhasa.

Ambient concentrations are commonly used as proxies for personal PM exposure in epidemiological studies, despite indoor settings being the places where people spend most of their time. In a panel study of 110 nonsmoking, healthy college students in Lhasa, Tibet, indoor PM was monitored using calibrated low-cost sensors for two multiweek periods, in over 40 dormitories where participants resided. We also repeatedly measured fractional exhaled nitric oxide (FeNO), an acute respiratory inflammation biomarker, for each participant.

SIRT2-mediated deacetylation of glutathione transferase alleviates oxidative damage and increases the heat tolerance of Pleurotus ostreatus.

High-temperature stress (HS) severely threatens agricultural production. Pleurotus ostreatus is cultivated in many parts of the world, and its growth is strongly affected by HS. We previously reported that metabolic rearrangement occurred in HS, but the gene expression levels of several key enzymes remained unchanged.

Proteomics of severe SARS-COV-2 infection and paraquat poisoning in human lung tissue samples: comparison of microbial infected and toxic pulmonary fibrosis.

Introduction: Pulmonary fibrosis (PF) encompasses a spectrum of lung conditions characterized by the abnormal accumulation of scar tissue in the lungs, leading to impaired respiratory function. Various conditions can result in severe PF, among which viral infections have emerged as significant triggers. In addition to viral infections, exposure to toxic substances such as paraquat represents another significant risk factor for PF.

Alteration of the health effects of bioaerosols by chemical modification in the atmosphere: A review.

Bioaerosols are a subset of important airborne particulates that present a substantial human health hazard due to their allergenicity and infectivity. Chemical reactions in atmospheric processes can significantly influence the health hazard presented by bioaerosols; however, few studies have summarized such alterations to bioaerosols and the mechanisms involved. In this paper, we systematically review the chemical modifications of bioaerosols and the impact on their health effects, mainly focusing on the exacerbation of allergic diseases such as asthma, rhinitis, and bronchitis.

The influence of crystal facet on the catalytic performance of MOFs-derived NiO with different morphologies for the total oxidation of propane: The defect engineering dominated by solvent regulation effect.

Crystal facet and defect engineering are crucial for designing heterogeneous catalysts. In this study, different solvents were utilized to generate NiO with distinct shapes (hexagonal layers, rods, and spheres) using nickel-based metal-organic frameworks (MOFs) as precursors. It was shown that the exposed crystal facets of NiO with different morphologies differed from each other.

The grading diagnostic strategy of molecular autopsy combined with pathological autopsy in the forensic diagnosis of cardiomyopathy.

The diagnosis of cardiomyopathy often relies on the subjective judgment of pathologists due to the variety of morphologic changes in the condition and its low specificity. This uncertainty can contribute to unexplained sudden cardiac deaths (USCD). To enhance the accuracy of hereditary cardiomyopathy diagnosis in forensic medicine, we proposed a combination of molecular autopsy and pathologic autopsy.

Effects of Heat Stress and Exogenous Salicylic Acid on Secondary Metabolites Biosynthesis in (Jacq.) P. Kumm.

(Jacq.) P. Kumm has high medicinal value, but few studies exist on regulating secondary metabolite biosynthesis.

Salicylic Acid Enhances Heat Stress Resistance of (Jacq.) P. Kumm through Metabolic Rearrangement.

(Jacq.) P. Kumm is cultivated worldwide, and its growth is seriously threatened by heat stress.

Organic Components of Personal PM Exposure Associated with Inflammation: Evidence from an Untargeted Exposomic Approach.

Fine particulate matter (PM) can promote chronic diseases through the fundamental mechanism of inflammation; however, systemic information is lacking on the inflammatory PM components. To decipher organic components from personal PM exposure that were associated with respiratory and circulatory inflammatory responses in older adults, we developed an exposomic approach using trace amounts of particles and applied it on 424 personal PM samples collected in a panel study in Beijing. Applying an integrated multivariate and univariate untargeted strategy, a total of 267 organic compounds were filtered and then chemically identified according to their association with exhaled nitric oxide (eNO)/interleukin (IL)-6 or serum IL-1β/IL-6, with monocyclic and polycyclic aromatic compounds (i.

Toxicity, biodistribution and oxidative damage caused by zirconia nanoparticles after intravenous injection.

As a promising nanomaterial for biomedical applications, zirconia nanoparticles (ZrO) have aroused concern recently, but the toxicity of ZrO in vivo has received little attention. The aim of this study is to demonstrate the systematic single dose toxicity, biodistribution and oxidative damage of ZrO in vivo after intravenous injection in mice. Ten ICR mice were used at the high dose of ZrO including 600, 500, 400 and 300mg/kg.

Copper-catalyzed C-S direct cross-coupling of thiols with 5-arylpenta-2,4-dienoic acid ethyl ester.

A selective copper (Cu)-catalyzed C-S bond direct cross-coupling of thiols with 5-arylpenta-2,4-dienoic acid ethyl ester was developed. Notably, various biologically active 5-phenyl-3-phenylsulfanylpenta-2,4-dienoic acid ethyl ester derivatives were efficiently synthesized under moderate conditions. Finally, a plausible Cu(i)/Cu(iii) reaction mechanism was proposed.

Laser-Induced Antibacterial Activity of Novel Symmetric Carbazole-Based Ethynylpyridine Photosensitizers.

In this study, two kinds of novel carbazole-based ethynylpyridine salts: 3,6-bis[2-(1-methylpyridinium)ethynyl]-9-pentyl-carbazole diiodide (BMEPC) and 3,6-bis[2-(1-methylpyridinium)ethynyl]-9-methyl-carbazole diiodide (BMEMC) have been employed as photosensitizers owing to their excellent antibacterial activity. These molecules possess symmetric A-π-D-π-A-type structures, which would bring in the unique optical properties. The inhibition zone measurement of a gradient concentration from 0 to 100 μM showed BMEPC and BMEMC photoinduced antibacterial activity against .

Enhanced antibacterial activity of silica nanorattles with ZnO combination nanoparticles against methicillin-resistant Staphylococcus aureus.

Silica nanorattles (SNs) with zinc oxide (ZnO) combination nanoparticles are reported to inhibit methicillin-resistant Staphylococcus aureus (MRSA) for the first time. SNs loaded with ZnO nanoparticles, which can produce free radicals, can cause severe damage to bacteria. ZnO nanoparticles not only provide free radicals in the combined nanostructures, which can inhibit the growth of bacteria, but also form nanorough surfaces with an irregular distribution of spikes on the SNs, which can enhance their adhesion to bacteria.

Imaging-guided synergetic therapy of orthotopic transplantation tumor by superselectively arterial administration of microwave-induced microcapsules.

It is an ambitious target to improve overall Hepatocellular Carcinoma therapeutic effects. Recently, MW ablation has emerged as a powerful thermal ablation technique, affording favorable survival with excellent local tumor control. To achieve better therapeutic effects of MW ablation, MW sensitizers are prepared for enhanced MW ablation to preferentially heat tumor territory.