Phytochemical composition and antioxidant capacity of three malian medicinal plant parts.

This study evaluates the levels of total polyphenolic compounds in three Malian medicinal plants and determines their antioxidant potential. Quantitative and qualitative analysis of polyphenolics contained in plants extracts were carried out by RP-C18 RP-HPLC using UV detector. The antioxidant activity was determined by three tests.

The antioxidant effect of plums and polyphenolic compounds against H(2)O(2)-induced oxidative stress in mouse blood granulocytes.

Epidemiological and scientific research has contributed to the identification of the key role of dietary antioxidants in maintaining human health by preventing oxidative damage to cellular components. The antiradical activity of seven varieties of plums and their protective effects against oxidative stress were comparatively evaluated in mouse granulocytes in this study using a 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) test and a cellular test. The class of phytochemical compounds responsible for the main antioxidant capacities observed was also investigated.

Evidence that oxidative stress is linked to anxiety-related behaviour in mice.

Oxidative stress in central and peripheral systems is involved in many diseases, including cancer, cardiovascular diseases, neurodegenerative diseases and several psychiatric disorders. In the present study, the brain and peripheral oxidative status of non-anxious and anxious mice was evaluated using 2',7'-dichlorofluorescin diacetate (DCFH-DA), a sensor of reactive oxygen species (ROS). Here we report that anxiety levels are linked to the oxidative status in both neuronal and glial cells in the cerebellum and hippocampus, in neurons of the cerebral cortex and in peripheral leucocytes (monocytes, granulocytes and lymphocytes), revealing the presence of oxidative stress in the central and peripheral systems of anxious mice.

The impact of high anxiety level on the oxidative status of mouse peripheral blood lymphocytes, granulocytes and monocytes.

Anxiety has been implicated in a number of psychiatric disorders, such as generalized anxiety disorder, depression, panic attacks, phobias, obsessive-compulsive disorders and posttraumatic stress disorders. In this study, we investigated the impact of high anxiety on the levels of intracellular reactive oxygen species in lymphocytes, granulocytes and monocytes from the peripheral blood of mice by using a 2',7'-dichlorofluorescein diacetate (DCFH-DA) probe. The behavioural light/dark choice test was used to distinguish highly anxious from less anxious mice.

Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects.

Background: Oxidative stress is linked to neurodegenerative diseases, cancer, cardiovascular diseases and to some behaviors, such as anxiety and depression. In particular, recent research observed a close relationship between oxidative stress and anxiety.

Methods: We investigated the anxiolytic effect of chlorogenic acid, a dietary antioxidant present in fruits, in mouse models of anxiety including the light/dark test, the elevated plus maze and the free exploratory test.

Positive correlation between peripheral blood granulocyte oxidative status and level of anxiety in mice.

Oxidative stress is involved in many acute and chronic diseases including cancer, cardiovascular disorders and neurodegenerative diseases. We studied the relationship between the level of intracellular reactive oxygen species in peripheral granulocytes and the estimated anxiety level of mice using the behavioral light/dark choice test. Our results indicate a linear and significant relationship between the intracellular redox status of peripheral blood granulocytes and different parameters of anxiety-related behavior including latency time (R(2)=0.