Publications by authors named "Chae Yeong Kang"
Article Synopsis
- A study focused on identifying genetic variants linked to schizophrenia specifically in the Korean population, as previous large-scale studies mainly involved individuals of European ancestry.
- Researchers recruited 1,670 schizophrenia patients and 2,271 healthy controls, testing over 6.6 million SNPs, and discovered a significant new variant (rs2423464) associated with the condition.
- The polygenic risk scores (PRS) derived from a combination of East Asian and European GWASs were more effective in explaining the genetic variance in schizophrenia among Koreans than those from single-ancestry studies.
Background And Hypothesis: The brain-predicted age difference (brain-PAD) may serve as a biomarker for neurodegeneration. We investigated the brain-PAD in patients with schizophrenia (SCZ), first-episode schizophrenia spectrum disorders (FE-SSDs), and treatment-resistant schizophrenia (TRS) using structural magnetic resonance imaging (sMRI).
Study Design: We employed a convolutional network-based regression (SFCNR), and compared its performance with models based on three machine learning (ML) algorithms.
Article Synopsis
- Virtual reality-based mindfulness (VBM) was tested as a potential tool for enhancing mindfulness in patients with psychosis, alongside a control group using standard VR scenes.
- The study involved 64 participants over 8 weekly sessions, with assessments measuring mindfulness and psychiatric symptoms before and after the intervention.
- Results indicated that while VBM showed some benefits in decentering and relationship motivations, overall, it was not significantly more effective than the control group and had mild adverse effects like VR sickness.
Article Synopsis
- The study focused on identifying key factors that influence recovery in patients with early stage schizophrenia spectrum disorders (SSD) over a follow-up period of up to 6.5 years.
- Researchers evaluated 375 patients using strict criteria for full recovery, including specific scores on the Positive and Negative Syndrome Scale (PANSS) and adequate functional recovery.
- The findings revealed that factors like negative symptoms, duration of untreated psychosis, and job status were significant predictors of recovery, emphasizing the importance of tailored treatment strategies based on individual clinical conditions.
Background: Brain age is a popular brain-based biomarker that offers a powerful strategy for using neuroscience in clinical practice. We investigated the brain-predicted age difference (PAD) in patients with schizophrenia (SCZ), first-episode schizophrenia spectrum disorders (FE-SSDs), and treatment-resistant schizophrenia (TRS) using structural magnetic resonance imaging data. The association between brain-PAD and clinical parameters was also assessed.
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- * Data analysis from 1986 to 2019 shows a rising number of ESRD patients in Korea, surpassing 100,000 in 2019, with a notable increase in elderly patients and a plateau in diabetes as the main cause.
- * Despite the increase in ESRD incidence, patient survival rates have improved over the years, but cardiovascular complications remain the leading cause of death among these patients, highlighting the need for better monitoring and intervention strategies.