Publications by authors named "Chae Min Yuk"
Article Synopsis
- Natural killer (NK) cells, which play a key role in fighting tumors, are hindered by transforming growth factor β1 (TGFβ1) in the tumor environment, leading to ineffective cancer therapies and poorer patient outcomes.
- The study develops a new type of self-activating chimeric antigen receptor (CAR)-NK cells that can block TGFβ1 signaling by releasing a peptide called P6, specifically targeting pancreatic tumors.
- P6 disrupts the negative signaling from TGFβ1 in NK cells, improving their function and ability to attack pancreatic tumors, showing promising results in both lab cultures and animal models, thus advancing cancer immunotherapy.
Despite the essential roles of natural killer (NK) cells in cancer treatment, the physical barrier and biological cues of the tumor microenvironment (TME) may induce NK cell dysfunction, causing their poor infiltration into tumors. The currently available two-dimensional (2D) cancer-NK co-culture systems hardly represent the characteristics of TME and are not suitable for tracking the infiltration of immune cells and assessing the efficacy of immunotherapy. This study aims to monitor NK-mediated cancer cell killing using a polymer thin film-based, 3D assay platform that contains highly tumorigenic cancer spheroids.
View Article and Find Full Text PDFBasophils are rare, circulating granulocytes proposed to be involved in T helper (T) type 2 immunity, mainly through secretion of interleukin (IL)-4. In addition to IL-4, basophils produce IL-6 and tumor necrosis factor (TNF)-α in response to immunoglobulin E (IgE) crosslinking. Differentiation of T17 cells requires IL-6 and transforming growth factor (TGF)-β, but whether basophils play a significant role in T17 induction is unknown.
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