Publications by authors named "Chae Lin Kang"
Severe glomerular injury ultimately leads to tubulointerstitial fibrosis that determines patient outcome, but the immunological molecules connecting these processes remain undetermined. The present study addressed whether V-domain Ig suppressor of T cell activation (VISTA), constitutively expressed in kidney macrophages, plays a protective role in tubulointerstitial fibrotic transformation after acute antibody-mediated glomerulonephritis. After acute glomerular injury using nephrotoxic serum, tubules in the VISTA-deficient (Vsir-/-) kidney suffered more damage than those in WT kidneys.
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- A randomized controlled trial was conducted to compare cardiovascular outcomes of expanded hemodialysis (HDx) using medium cutoff (MCO) membranes to online hemodiafiltration (online-HDF) in 80 patients undergoing thrice-weekly hemodialysis.
- Primary endpoints included changes in brachial-ankle pulse wave velocity (baPWV), echocardiographic measures, and coronary artery calcium (CAC) scores over one year, with 65 patients completing the trial.
- Results showed no significant differences in most cardiovascular parameters between the two groups, but CAC scores increased in the HDx group, suggesting caution when switching from online-HDF to HDx for patients with high or rising