Effectiveness of febuxostat in patients with allopurinol-refractory hyperuricemic chronic kidney disease .

Objective: As uncontrolled hyperuricemia has been associated with an increased risk of cardiovascular disease and the progression of chronic kidney disease (CKD), management of serum uric acid levels is important. The aim of this study was to evaluate the effectiveness of febuxostat in regulating uncontrolled hyperuricemia in patients with renal dysfunction.

Materials And Methods: We included patients with CKD and persistent uncontrolled hyperuricemia despite treatment with allopurinol.