Publications by authors named "Chad R Altobelli"
p97, also known as valosin-containing protein, is an essential cytosolic AAA+ (ATPases associated with diverse cellular activities) hexamer that unfolds substrate polypeptides to support protein homeostasis and macromolecular disassembly. Distinct sets of p97 adaptors guide cellular functions but their roles in direct control of the hexamer are unclear. The UBXD1 adaptor localizes with p97 in critical mitochondria and lysosome clearance pathways and contains multiple p97-interacting domains.
View Article and Find Full Text PDFp97/VCP is an essential cytosolic AAA+ ATPase hexamer that extracts and unfolds substrate polypeptides during protein homeostasis and degradation. Distinct sets of p97 adapters guide cellular functions but their roles in direct control of the hexamer are unclear. The UBXD1 adapter localizes with p97 in critical mitochondria and lysosome clearance pathways and contains multiple p97-interacting domains.
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- Parthenolide, derived from the feverfew plant, shows anti-inflammatory and anti-cancer properties, and this study aims to understand its mechanism in breast cancer cells.
- Using advanced chemoproteomic techniques, researchers discovered that parthenolide covalently modifies a specific cysteine in focal adhesion kinase 1 (FAK1), disrupting its signaling pathways.
- This impairment results in reduced breast cancer cell growth, survival, and movement, highlighting an important target for other natural anti-cancer compounds.