Publications by authors named "Chad Phillips"

Article Synopsis
  • Extrachromosomal circular DNA (ecDNA) is commonly found in various human cancers, particularly in oropharyngeal cancer linked to the human papillomavirus (HPV), but its role in cancer development is not fully understood.
  • Researchers studied the epigenetic characteristics of hybrid ecDNA in HPV-positive oropharyngeal cancer cell lines and tumor models, discovering that HPV oncogenes E6/E7 are associated with unique enhancer regions.
  • By using targeted therapies, such as CRISPR interference and specific inhibitors, they were able to decrease E6/E7 gene expression and inhibit tumor growth, highlighting the potential for new treatments that target ecDNA-driven cancer biology.
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Telephone intervention may address the need for problem-solving interventions to improve medication adherence in patients with schizophrenia spectrum disorders (SSDs). The current randomized controlled trial examined the effect of weekly telephone intervention problem solving (TIPS) on quantitative measures of psychiatric and nonpsychiatric medication adherence over 6 months in 105 stable outpatients with SSDs. Independent samples t test revealed no significant differences in psychiatric or nonpsychiatric pill count adherence between groups at 6 months; however, 54.

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We conducted a randomized controlled trial to determine the effect of weekly telephone intervention upon self-reported medication adherence, medication adherence self efficacy, and symptom levels in 140 stable outpatients with SSDs for three months. To our knowledge, this is the first study examining medication adherence self efficacy in persons with SSDs. Study measures were administered in a private office by trained study staff immediately following the granting of informed consent, and again after three months.

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The problem of medication adherence in schizophrenia spectrum disorders (SSDs) has challenged researchers and clinicians for decades. Few investigations have examined non-psychiatric adherence in this group. We conducted a descriptive correlational investigation of adherence and related factors in 185 stable outpatients with SSDs.

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Problem-solving interventions are not routinely offered to persons with schizophrenia spectrum disorders (SSDs). Telephone calls and text messages are potential avenues to offer problem solving support. This study compared the effect of telephone calls only, text messages only, and both telephone calls and text messages on individuals' symptoms and medication adherence.

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