Impact of Ticagrelor Versus Clopidogrel on Bleeding Outcomes of Isolated Coronary Artery Bypass Grafting.

Background: Increased bleeding risks have been documented in patients exposed to P2Y inhibitors within 5 days of coronary artery bypass surgery (CABG). This study aimed to determine the relative CABG bleeding risks of clopidogrel versus ticagrelor exposure and the proper time course of ticagrelor discontinuation prior to surgery.

Methods: Clinical outcomes were assessed in 2075 isolated CABG patients, including 375 who had received P2Y inhibitors within 5 days of surgery (155 clopidogrel, 213 ticagrelor, 7 prasugrel).

Heart Rate and Neurological Outcomes in Patients Undergoing Targeted Temperature Management.

Introduction: There is a paucity of data evaluating the impact of heart rate (HR) during Targeted Temperature Management (TTM) and neurologic outcomes. Current resuscitation guidelines do not specify a HR goal during TTM. We sought to determine the relationship between HR and neurologic outcomes in a single-center registry dataset.