Sorption of cholesterol and other bile components on ion-exchangers in vitro, and their influence on the cholesterol level in human serum in vivo.

The sorption of bile acids, bilirubin, bilirubin glucuronates and cholesterol on ion-exchange resin is described. After some successful attempts of sorption of these substances from human and animal bile in vitro, this exchanger has been used in human therapy. Positive results obtained showed the usefulness of the method.

Histamine binding proteins separated from human sera by the chromatographic method.

Human serum proteins were bound on and eluted from sepharose-polylysine-histamine column. Thus obtained protein fraction was referred to as HBP (Histamine Binding Protein). HBP proteins were examined for the ability to bind histamine by biologic method applied to isolated guinea pig intestine.

Histamine binding proteins in allergic diseases.

The present studies deal with histamine binding by some serum proteins of persons with allergic disorders and of normal subjects. It was found, that a defect in histamine inactivation occurs in patients with infectious bronchial asthma. There was no impairment of histaminopexy in the cases of hay fever and Quincke's edema.

Intal (sodium cromoglycate) therapy in ulcerative colitis.

Intal was applied intrarectally for the treatment of ulcerative colitis in 39 patients with active pathological process. The drug was insufflated by means of rectoscopic tube at the dosage of 200 mg capsules daily for 15 days. Complete remission of the disease has been achieved in 97 per cent of patients within 2 weeks of the administration of the drug.