A new efficient catalytic system for the chemoselective cobalt-catalyzed cross-coupling of aryl Grignard reagents with primary and secondary alkyl bromides.

The cobalt-catalyzed alkylation of aromatic Grignard reagents is performed in good yields by using a new simple and efficient catalytic system: CoCl(2)/TMEDA (1:1). Primary and secondary cyclic or acyclic alkyl bromides were used successfully. The reaction is highly chemoselective since ester, amide, and keto groups are tolerated.

Iron-catalyzed homo-coupling of simple and functionalized arylmagnesium reagents.

Iron-catalyzed homo-coupling of simple and functionalized arylmagnesium reagents is described. The reaction is highly chemoselective (CN, COOEt and NO(2) groups are tolerated). The procedure was used to perform intramolecular couplings.

[Universal dyschromatosis: a familial case].

Introduction: Universal dyschromatosis is a generalized leucomelanodermia recognised in Japan in 1933. We report a family with universal dyschromatosis, demonstrating the mode of transmission. The ultrastructural aspects are compatible with a functional melanogenesis anomaly.

[Maternal fetal choriocarcinoma after normal delivery].

Materno-fetal choriocarcinoma discovered after a normal delivery is very rare. The risks for choriocarcinoma after a pregnancy at term is estimated at 1 in 100,000. All the same the ease with which the diagnosis is made by levels of plasma beta-hCG makes it possible to think of this possibility after delivery when there is maternal pathology which cannot be diagnosed or a fetal tumour that cannot be labelled.

[Shwachman's syndrome with neonatal thoracic manifestations].

The authors report a case of Shwachman's syndrome in whom neonatal respiratory distress was the initial manifestation. Metaphyseal dysplasia, which was severe at birth, progressively disappeared. By the age of 10 years, radiologic anomalies persist only in the pelvis.

[Myoglobinuria following anesthesia (author's transl)].

In a 11 1/2 year-old boy, acute myolysis with myoglobinuria followed anesthesia and had a favourable outcome. Biological signs of myolysis, without clinical symptoms seem to be frequent after Halothane-succinylcholine anesthesia. They are even more frequent in children, especially when succinylcholine is repeatedly given during Halothane anesthesia.