Synthesis and biological evaluation of new 4-oxo-thiazolidin-2-ylidene derivatives as antimicrobial agents.

In this study, an efficient synthesis and the antimicrobial activity evaluation of some 4-oxo-thiazolidin-2-ylidene derivatives are presented. The structures of the target substances were confirmed by using H and C nuclear magnetic resonance spectroscopy, mass spectrometry, infrared spectroscopy, and elemental analysis. The synthesized compounds were evaluated for antimicrobial activity against five bacterial strains (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus) and two fungal strains (Candida albicans and Cryptococcus neoformans).

Synthesis, Molecular Docking and Biological Properties of Novel Thiazolo[4,5-b]pyridine Derivatives.

The synthesis, anti-inflammatory and antioxidant properties of novel 5-hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one derivatives were discussed. Fused thiazolo[4,5-b]pyridin-2-ones were synthesized and modified at the N3, C5 and C6 positions of the main core in order to obtain the compounds with a satisfactory pharmacological profile. The synthesized compounds were preselected via molecular docking for further testing of their anti-inflammatory activity in vitro.

A New Reagent for Spectrophotometric Determination of Ir(IV): 5-[2-(4-Hydroxyphenyl) hydrazineylidene]- 4-iminothiazolidin-2-one (HPIT).

The paper presents a new azolidone derivative - 5-[2-(4-hydroxyphenyl)hydrazineylidene]-4-iminothiazolidin-2-one (HPIT) studies and its interaction results with iridium(IV) ions. The Ir(IV) with this reagent in the pH = 5.0 without heating forms a stable complex (?max = 328 nm).

Spectrophotometric Determination of Ru(IV) Using 5-Hydroxyimino-4-imino-1,3-thiazolidin-2-one as a Novel Analytical Reagent.

The interaction of Ru(IV) ions with a novel analytical reagent - 5-hydroxyimino-4-imino-1,3-thiazolidin-2-one, by spectrophotometric method was investigated. The complex is formed at pH 5.0 in acetate buffer medium after heating in the boiling water bath (~371 K) for 25 min.

ynthesis, Anti-Inflammatory and Antioxidant Activities of Novel 3H-Thiazolo[4,5-b]Pyridines.

5-Hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one was obtained by the reaction of 4-iminothiazolidin-2-one with acetoacetic ester. Further structural modifications include the introduction of diversity at the C5 and C6 positions. The anti-inflammatory action of novel thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vivo employing the carrageenan- induced rat paw edema method.

Spectrophotometric studies of 4-[N'-(4-imino-2-oxo-thiazolidin-5-ylidene)-hydrazino]-benzenesulfonic acid as a reagent for the determination of palladium.

The spectrophotometric behavior of a new, first-time synthesized reagent - 4-[N'-(4-imino-2-oxo-thiazolidin-5-ylidene)hydrazino]-benzenesulfonic acid (ITHBA), has been investigated. A simple, rapid, accurate, selective and sensitive method for the spectrophotometric determination of Pd(II) ions using this reagent was developed. The optimal conditions for the formation of the complexes were found.

[Lipid peroxidation, antioxidative system and platelet component of homeostasis in patients with infectious mononucleosis].

The authors consider parameters of lipid peroxidation, antioxidative system and platelet component of homeostasis in patients with infectious mononucleosis.

Effect of epithalon on age-specific changes in the retina in rats with hereditary pigmentary dystrophy.

The effect of peptide bioregulator Epithalon on the course of hereditary pigmentary retinal degeneration was studied in Campbell rats. Administration of epithalon starting from birth protected morphological structure, increased its bioelectrical activity, and improved its function.

[The comparative dynamic characteristics of the autonomic indices of the cardiovascular system in myocardial infarct patients].

A study was made of the vegetative parameters associated with the cardiac rhythm and central hemodynamics in 60 patients with myocardial infarction. In 45 patients the time course of the urinary excretion of catecholamines was examined. Regulation of cardiovascular system in patients with myocardial infarction in different time spells of the disease course was studied in relation to the particular features of the clinical picture and presence of complications.

[The diagnosis and correction of psychogenic disorders in myocardial infarct patients at the rehabilitation stages].

The mental status was evaluated in 179 males on the 17-20 and 35-45 days and 6 months after myocardial infarction. The psychoemotional state was studied in these patients at rehabilitation stages. There was a relationship between the neurotization level and frequency of cardialgia, severity of the disease and tolerance to physical load.