Characteristics of DRESS Syndrome in the Elderly: A Comparative Study of 55 Patients.

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare drug reaction characterized by a skin rash, eosinophilia, and organ involvement. Our purpose is to focus on the clinical and epidemiological characteristics of DRESS in the elderly and to identify the incriminated drugs. This is a retrospective study including patients, hospitalized for DRESS with a RegiSCAR ≥4.

An unusual pigmented skin lesion on the nipple-areola area.

Considering the rarity and underdiagnoses of this disorder, a pigmented and hyperkeratotic skin lesion located on the trunk, resembling to acanthosis nigricans should always be investigated for terra firma-forme dermatosis (TFFD) and thus alcohol must be applied. TFFD should be known among dermatologists and can be easily diagnosed and treated with isopropyl alcohol.

Clinical and genetic investigation of ichthyosis in familial and sporadic cases in south of Tunisia: genotype-phenotype correlation.

Background: Ichthyosis is a heterogeneous group of Mendelian cornification disorders that includes syndromic and non-syndromic forms. Autosomal Recessive Congenital Ichthyosis (ARCI) and Ichthyosis Linearis Circumflexa (ILC) belong to non-syndromic forms. Syndromic ichthyosis is rather a large group of heterogeneous diseases.

[A rare cause of AA amyloidosis: Hereditary epidermolysis bullosa].

Introduction: Recessive dystrophic epidermolysis bullosa is a rare genetic condition characterized by fragile skin and mucous membrane, caused by mutations in the COL7A1 gene. AA amyloidosis is a rare complication of these genodermatosis.

Observations: Two patients with recessive dystrophic epidermolysis bullosa, generalized severe in the first case and generalized intermediate in the second case, developed at the age of 38 and 28, respectively, nephrotic syndrome.

Communicating artificial neural networks develop efficient color-naming systems.

Words categorize the semantic fields they refer to in ways that maximize communication accuracy while minimizing complexity. Focusing on the well-studied color domain, we show that artificial neural networks trained with deep-learning techniques to play a discrimination game develop communication systems whose distribution on the accuracy/complexity plane closely matches that of human languages. The observed variation among emergent color-naming systems is explained by different degrees of discriminative need, of the sort that might also characterize different human communities.

Hydroxychloroquine-induced acute generalized exanthematous pustulosis: a series of seven patients and review of the literature.

Background: Hydroxychloroquine (HCQ)-induced acute generalized exanthematous pustulosis (AGEP) is poorly described in the literature. The aim of our study was to characterize the clinical, laboratory, allergological, and genetic features of HCQ-induced AGEP.

Methods: We conducted a retrospective study of patients with HCQ-induced AGEP diagnosed between 2011 and 2019.

Purification and biochemical characterization of an acid-stable lipase from the pyloric caeca of sardine (Sardinella aurita).

A lipolytic activity was located in the sardine digestive glands (pyloric caeca), from which a sardine digestive lipase (SaDL) was purified. Pure SaDL has a molecular mass of 43 kDa as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis. The enzyme was found to be more active on short-chain triacylglycerols than on long-chain ones.