Evaluating Performance Among National Basketball Association Players After Jones Fractures: A Retrospective Cohort Study.

Background: In professional basketball, Jones fractures are among the most common cause of lower extremity stress injury. Despite its prevalence, there is a paucity of research on the impact of Jones fractures on athletic performance in the National Basketball Association (NBA).

Purpose: To determine the impact of Jones fractures on return to play and performance among NBA players when compared with preinjury values and healthy matched controls.

Medicare and Medicaid patients undergoing total joint arthroplasty have more complications and healthcare utilization than privately insured patients.

Aims & Objectives: This study characterized the independent association between insurance type and healthcare outcomes in patients undergoing total joint arthroplasty (TJA).

Materials &methods: National data identified patients who underwent total hip, knee, shoulder, elbow, ankle or wrist joint arthroplasty surgery from 2012 to 2020 for osteoarthritis. Medicaid, Medicare≥65 years old, Medicare<65 years old, and uninsured patients were matched to privately insured patients based on age, sex, and comorbidities.

Elucidation and engineering of Sphingolipid biosynthesis pathway in Yarrowia lipolytica for enhanced production of human-type sphingoid bases and glucosylceramides.

Sphingolipids are vital membrane components in in mammalian cells, plants, and various microbes. We aimed to explore and exploit the sphingolipid biosynthesis pathways in an oleaginous and dimorphic yeast Yarrowia lipolytica by constructing and characterizing mutant strains with specific gene deletions and integrating exogenous genes to enhance the production of long-chain bases (LCBs) and glucosylceramides (GlcCers). To block the fungal/plant-specific phytosphingosine (PHS) pathway, we deleted the SUR2 gene encoding a sphinganine C4-hydroxylase, resulting in a remarkably elevated secretory production of dihydrosphingosine (DHS) and sphingosine (So) without acetylation.

Increasing Very Low-Dose Edoxaban Prescription: Effectiveness and Safety Data of Korean AF Patients.

Background And Objectives: Evidence remains limited on the real-world prescription of very low-dose oral anticoagulation among frail patients with atrial fibrillation (AF). We described the practice patterns, effectiveness, and safety of very low-dose edoxaban (15 mg once daily).

Methods: Patients with AF prescribed edoxaban 15 mg once daily in 2 tertiary hospitals between 2016 and September 2022 were included.

Age and Clinically Actionable Events in Patients With Implantable Loop Recorders: Analysis of Multicenter Loop Recorder Registry.

Introduction: Little is known about age and clinical intervention after implantable loop recorder (ILR) insertion. This study investigated the association between age and clinical intervention after ILR implantation.

Methods And Results: Data were obtained from a multicenter registry of ILR in Korea (2017-2020, n = 795).

Clinical Outcome of Cryoballoon Ablation for Long-Standing Persistent Atrial Fibrillation: From the Korean Cryballoon Ablation Registry.

Introduction: Pulmonary vein isolation (PVI) by cryoballoon ablation (CBA) is considered an effective primary strategy for early persistent atrial fibrillation (AF). However, data regarding CBA for long-standing persistent AF (PeAF) are limited. We evaluated the efficacy and safety of CBA for long-standing PeAF compared to PeAF.

Safeguarding the brain from oxidative damage.

Oxidative stress imposes a substantial cellular burden on the brain and contributes to diverse neurodegenerative diseases. Various antioxidant signaling pathways have been implicated in oxidative stress and have a protective effect on brain cells by increasing the release of numerous enzymes and through anti-inflammatory responses to oxidative damage caused by abnormal levels of reactive oxygen species (ROS). Although many molecules evaluated as antioxidants have shown therapeutic potentials in preclinical studies, the results of clinical trials have been less than satisfactory.

Photofragmentation laser-induced fluorescence imaging of CH by structured illumination in a plasma discharge.

Methyl is crucial in plasma-assisted hydrocarbon chemistry, making precise in situ imaging essential for understanding various plasma applications. Its importance in methane chemistry arises from its role as a primary byproduct during the initial phase of methane dehydrogenation. Detecting the CH radical is challenging due to its high reactivity and the prevalence of strongly pre-dissociative electronically excited states.

Isolated Left Extensor Hallucis Longus Palsy Secondary to Deep Peroneal Nerve Injury in a 15-Year-Old Boy: A Case Report.

Introduction: Nerve palsies are potential consequences of fractures that can result in temporary loss of muscular function. Nerve palsies have not been extensively described in the context of tibial tubercle fractures in the pediatric population. Although the symptoms accompanying nerve palsies concern patients, evidence suggests that non-operative management often results in full functional recovery over time.

Regeneration of a Discoid Meniscus: A Case Report.

Case: A 4-year-old girl with no relevant medical history presented with left knee swelling. Knee laxity, magnetic resonance imaging findings of anterior cruciate ligament (ACL) deficiency and discoid meniscus, and the chronicity of symptoms prompted arthroscopic ACL reconstruction and meniscal saucerization. Pain and swelling continued, and repeat arthroscopy revealed regeneration of the discoid meniscus at 18-month follow-up.

Quaternarized chitosan nanofiber and ZIF aerogel composites for synergetic CO cycloaddition catalysis.

Chemical upcycling of CO, a major greenhouse gas, is attracting significant attention as a crucial strategy to combat global warming. The production of cyclic carbonate using metal-organic frameworks and their composites using nanofibrous carbohydrate polymer are promising ways to convert CO into valuable products. However, the current role of fibrous polymers is restricted to serving as physical substrates.

Temperature-Dependent Kinetics of Plasma-Based CO Conversion: Interplay of Electron-Driven and Thermal-Driven Chemistry.

The transformation of CO into chemical building blocks for various industries is considered a key technology in a net-zero energy future. To realize this, plasma discharges are one of the most promising approaches thanks to their electron-driven reactions and high operational flexibility. Most studies focused on room-temperature and vibrationally-excited discharges, however, lately, the importance of thermal reactions is considered.

Dietary Nutritional Supplements Are Associated with the Deterioration of Hepatic Fibrosis in Women and Individuals without Underlying Disease.

Despite the growing societal interest in the health benefits of dietary nutritional supplements, their safety and efficacy remain unclear. We aimed to investigate the correlation between hepatic fibrosis and the consumption of dietary nutritional supplements. This study utilized data from the Korea National Health and Nutrition Examination Survey spanning the period from 2014 to 2022.

Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein.

Immune checkpoint inhibitors have substantial advanced tumor treatment, but their limited benefits and strong responses in only a subset of patients remain challenging. In this study, we explored the immunomodulatory function of contactin-4 (CNTN4). CNTN4 was highly expressed in tumor tissues, and expression impaired the antitumor function of T cells.

Modulation of chemotherapy-induced peripheral neuropathy by JZL195 through glia and the endocannabinoid system.

Chemotherapy-induced peripheral neuropathy (CIPN) used to treat cancer, is a significant side effect with a complex pathophysiology, and its mechanisms remain unclear. Recent research highlights neuroinflammation, which is modulated by the endocannabinoid system (ECS) and associated with glial activation, and the role of toll-like receptor 4 (TLR4) in CIPN. This study aimed to investigate the effects of JZL195, an inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), and explore the connection between cannabinoid receptors and TLR4 in glial cells.

AMPK-Mediated Hypolipidemic Effects of a and Mixed Extract on High-Fat Diet-Induced Liver Triglyceride Accumulation: An In Vivo and In Vitro Study.

Background: This study investigates the hypolipidemic effects of a mixed extract of and (USCP119) in HFD-fed hamsters and in vitro cellular models.

Methods: Over an 8-week period, HFD-fed hamsters were assigned to one of six groups: normal diet, HFD control, HFD with 50 mg/kg USCP119, HFD with 100 mg/kg USCP119, HFD with 50 mg/kg USCP119 twice daily (BID), and HFD with omega-3 fatty acids. Key outcomes assessed included body weight, serum triglycerides (TG), total cholesterol (TC), liver weight, hepatic TG levels, and epididymal fat.

Drug Discovery and Screening Tool Development for Tauopathies by Focusing on Pathogenic Tau Repeat 3 Oligomers.

Comprehending early amyloidogenesis is essential for the development of effective therapeutic strategies. In tauopathies like Alzheimer's disease (AD), the abnormal accumulation of tau protein is initiated by pathological tau seeds. Mounting evidence implies that the microtubule binding domain, consisting of three to four repeats, plays a pivotal role in this process, yet the exact region driving the formation of pathogenic species needs to be further scrutinized.