Publications by authors named "Cha Kyong Yom"
Phyllodes tumors of breast (PTB) have been known to an uncommon and particular disease to handle owing to diagnostic ambiguity and unpredictable clinical outcome. Malignant phyllodes tumors (MPT) are diagnosed when there are marked stromal hypercellularity, atypia, increased mitoses of ≥10/10 HPFs, permeative tumor borders, and stromal overgrowth. The presence of a malignant heterologous element (MHE) places the tumor into the malignant category regardless of other histological features.
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- The study explored the link between isoflavone (ISF) intake and the risk of hereditary breast cancer (BC) among East-Asian women, focusing on BRCA1/2 mutation carriers and other high-risk groups.
- The research involved 1,709 participants and utilized hazard ratios and confidence intervals to assess the relationship between ISF consumption and different breast cancer subtypes.
- Findings indicated that higher ISF intake is associated with a lower risk of luminal A and triple negative breast cancer among BRCA mutation carriers and women with a family history of breast cancer.
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- This study evaluated the effectiveness of SMS reminders for improving breast self-examination (BSE) adherence among breast cancer surgery patients.
- Participants were split into two groups: one receiving monthly text reminders and cancer information, and a control group without these messages.
- Results showed that the intervention group had significantly higher BSE adherence and frequency over six months, highlighting SMS as a simple and cost-effective tool for promoting health behaviors.
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- The study investigates the treatment of phyllodes tumors of the breast (PTB), suggesting the need for a second resection to achieve a surgical margin of at least 1 cm, though outcomes raise questions about this practice.
- A retrospective analysis of 285 PTB cases from 1989 to 2008 was conducted, revealing that benign tumors generally recur as benign, with specific factors like tumor size and mitosis rate significantly impacting local recurrence rates.
- The findings recommend that wide excision with clear margins should be prioritized specifically for small PTB with high mitosis counts, potentially requiring a second surgery to minimize recurrence risk.
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- The study focused on the role of large genomic rearrangements (LGRs) in the BRCA1/2 genes among familial breast cancer patients who lacked small mutations.
- Researchers screened 221 patients using sequencing methods and a specific assay (MLPA) to identify both small mutations and LGRs.
- The findings indicated LGRs in 3.7% of the patients with BRCA1/2 mutations and recommend using MLPA as an initial screening method in high-risk cases for better detection of these genetic changes.
Background: Robotic thyroidectomy (RoT) is frequently performed due to its excellent cosmesis and recovery features. However, postoperative pain in the operating field after RoT remains a concern due to extensive tissue dissection and tension during the operation. The aim of this study was to evaluate the anterior chest pain and the effect of levobupivacaine spraying on postoperative pain control after bilateral axillo-breast approach (BABA) RoT.
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- IDO is highly expressed in papillary thyroid microcarcinoma (PTMC), which is linked to the activation of regulatory T cells (Treg) and decreased immune response, potentially contributing to tumor progression.
- A study involving 124 PTMC samples found that higher levels of IDO correlated with reduced CD3+ T cells and increased FOXP3+ Treg cells, indicating those tumors have more aggressive characteristics, such as extrathyroidal extension and multifocality.
- The results suggest that IDO expression and Treg infiltration may disrupt the body's immune response against tumors, serving as potential predictive factors for tumor behavior in PTMC patients.
Background: "Atypia of undetermined significance" (AUS) in the Bethesda System for Reporting Thyroid Cytopathology is a heterogeneous category for cases that cannot be easily classified into benign, suspicious, or malignant. This study evaluated whether cytomorphology-based subcategorization could better predict the malignancy risk in cases designated as AUS, and how the subcategories correlated with BRAF mutation status in thyroid fine-needle aspirates (FNA).
Methods: Of 3589 cases of thyroid FNA diagnosed at the authors' institution in Seongnam, Korea, from January 2010 to December 2011, 331 cases of AUS were reviewed and subcategorized based on cytomorphological features, including nuclear atypia (NA), microfollicle formation (MF), Hürthle cell change (HC), and others (O).
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- The study assessed quality of life differences among breast cancer patients based on their surgical treatment types: breast-conserving surgery, total mastectomy, and immediate reconstruction.
- A cross-sectional analysis involved 407 women who completed various quality of life questionnaires at least 2 years post-surgery.
- Results showed that those who underwent breast-conserving surgery reported better emotional and physical outcomes compared to those who had total mastectomy or reconstruction, highlighting the importance of surgical choices on quality of life.
Background: Sore throat, hoarseness, dysphagia, and cough are common laryngopharyngeal discomforts after thyroidectomy. The incidence and severity of laryngopharyngeal symptoms after the use of a flexible reinforced laryngeal mask airway (LMA) were compared with those that occur after the use of a plain endotracheal tube in patients after thyroidectomy.
Methods: Seventy-six patients scheduled for total thyroidectomy were randomized into a plain endotracheal tube group (group E) or a flexible reinforced LMA group (group L).
Purpose: Leptin is a potent adipokine that plays a significant role in tumor development and the progression of breast cancer. The aim of this study was to evaluate whether leptin affects the response to tamoxifen treatment in estrogen receptor (ER)-positive breast cancer cells.
Methods: Leptin, leptin receptor (Ob-R), and activation of signaling pathways were studied by Western immunoblotting.
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- The study aimed to identify factors influencing the choice to have risk-reducing salpingo-oophorectomy (RRSO) among women with BRCA1 or BRCA2 mutations in South Korea.
- Among 124 women reviewed, only 21 out of 71 eligible carriers chose RRSO, with a notable 52.6% of those in their 50s opting for the procedure.
- Key factors influencing the decision included age and a personal history of breast cancer, highlighting their importance in counseling BRCA1/2 mutation carriers.
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- The study investigated the re-excision rate after breast-conserving surgery (BCS) for breast cancer, revealing that 10.0% of patients needed re-excision, often leading to treatment delays and aesthetic issues.
- Factors linked to re-excision included younger age, non-palpable lesions, multifocality, and the presence of ductal carcinoma in situ (DCIS), emphasizing the need for careful surgical planning.
- The research found that tumor location affected resection margin outcomes, with notable differences in margin rates based on the tumor's position in the breast.
The primary aim of this study was to estimate the prevalence of BRCA1/2 mutations among familial breast cancer (BC) patients in Korea. We analyzed 775 familial BC patients who were enrolled in the Korean Hereditary Breast Cancer (KOHBRA) study and treated at 36 institutions between May 2007 and May 2010. Patients with familial BC were defined as BC patients with family histories of BC or ovarian cancer (OC) in any relatives.
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- Restricted shoulder mobility can impact quality of life after breast cancer surgery, and the study explored the effects of HA-CMC on recovery.
- A randomized controlled trial was conducted with 99 women, where one group received HA-CMC treatment post-mastectomy while the control group did not.
- Results showed that the HA-CMC group experienced improved shoulder range of motion and reduced pain after surgery, suggesting it could be a beneficial treatment for post-operative recovery.
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- The study compared the accuracy of MRI and ultrasound (US) in measuring the size of invasive breast cancer (IBC) and carcinoma in situ (CIS) in 1558 patients.
- Results showed that MRI was more precise than US for tumor size estimation; however, both imaging methods yielded similar outcomes in surgical procedure success and recurrence rates for patients undergoing breast-conserving surgery (BCS).
- Despite the improved accuracy of MRI for tumor measurement, the addition of routine MRI before BCS did not significantly enhance surgical outcomes, like re-excision rates or disease recurrence.
Prevalence and phenotype of BRCA mutation can vary by race. The purpose of this study is to evaluate the prevalence of BRCA1/2 mutations in non-familial breast cancer patients with high risks in Korea. A subset of 758 patients was selected for this study from the KOHBRA nationwide multicenter prospective cohort study.
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- ANXA1 expression is significantly reduced in ductal carcinoma in situ (DCIS) and invasive breast cancer compared to normal and benign tissues, suggesting its potential role as a biomarker.
- Analysis of breast tissue from 182 patients found that while ANXA1 positivity was linked to poor survival in univariate analysis, it was not significant in multivariate analysis, with HER2 overexpression and TNM staging being more critical for relapse-free survival.
- The study concludes that while ANXA1 exhibits decreased expression in breast cancer, its overexpression in invasive cases is associated with unfavorable prognostic factors, hinting at its complex role in breast cancer development.
Increased expression and activation of focal adhesion kinase (FAK) was reported to be an unfavorable factor in various human cancers, including breast cancer. In order to study FAK gene status as a prognostic factor, we evaluated FAK gene copy number and FAK protein expression in invasive breast cancer. Tumors from 435 patients with invasive breast cancer were evaluated for FAK gene status using fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) based on tissue array method.
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- The study evaluated the long-term outcomes of using ultrasound-guided vacuum-assisted biopsy devices (VABD) for excising benign breast tumors, with a focus on follow-up results.
- During the analysis of 184 cases (153 patients), the median follow-up was 33 months, revealing a 10% rate of residual lesions within 2 years and 6.5% after more than 2 years.
- The study concluded that VABD is an effective and minimally invasive method for completely excising benign breast tumors, with results similar to traditional surgical techniques.
Background: The prognostic significance of the antiapoptotic protein secretory clusterin overexpression in breast cancer is unclear.
Patients And Methods: Secretory clusterin expression was explained in three hundred and fifty-two patients with breast cancer by immunohistochemistry. Clusterin overexpression was tested for correlation with overall survival (OS) and relapse-free survival (RFS).
The aim of this study was to evaluate the difference in outcomes based on p53 overexpression of patients with breast cancer who received adjuvant therapy following local treatment for invasive ductal carcinoma, not otherwise specified. We analyzed data from 4,683 patients with cancer enrolled in two institutions between 1997 and 2006. We analyzed the correlation between p53 overexpression and relapse, response to adjuvant therapy, breast cancer-specific survival (BCSS), and relapse-free survival (RFS) in patients with primary breast cancer.
View Article and Find Full Text PDFBackground: Application of laparoscopy-assisted distal gastrectomy (LADG) for early gastric cancer (EGC) is still controversial because of scant evidence of long-term safety and feasibility. We evaluated the long-term outcome of LADG compared with conventional open distal gastrectomy (ODG) for EGC.
Methods: Between March 1999 and July 2006, 106 patients underwent LADG and 105 patients underwent ODG for EGC.
The adenosine triphosphate-based chemotherapy response assay (ATP-CRA) has the advantages of standardization, evaluability, reproducibility, and accuracy, and can be performed on relatively small numbers of tumor cells. A total of 43 patients were enrolled in the present study, and chemosensitivity tests were successfully performed in 40 (93.0%) of these patients.
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