Publications by authors named "Cha Dao-gang"
Background: Nitric oxide (NO) is protective for the cardiovascular system, and excessive NO exerts negative effects on the circulatory system. This study aimed to compare the effects of selective or non-selective NO synthase (NOS) inhibitors on blood flow perfusion of ischemia-reperfused myocardium.
Material And Methods: Male mongrel dogs were randomly assigned to 4 groups: only ischemia-reperfusion (control), ischemia-reperfusion plus Nù-nitro-L-arginine methyl ester (NAME) treatment, ischemia-reperfusion plus aminoguanidine (AMD) treatment, and sham operation group.
Effects of drag-reducing polymers on microcirculation of normal rat hindlimb skeletal muscle.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
April 2011
Objective: To observe the effects of polyethylene oxide (PEO) on microcirculation of normal rat hindlimb skeletal muscle.
Methods: Sixteen male Wistar rats were anesthetized and equally and randomly divided into PEO group (administered with 10 ppm PEO solution) and control group (administered with equal volume of normal saline). The PEO solution or saline was separately injected through the caudal vein at a constant rate of 5 ml/h for 20 minutes.
Article Synopsis
- - The study aimed to examine how coronary microcirculation changes during myocardial stunning in dogs after temporarily cutting off blood flow.
- - Male dogs underwent a specific occlusion of the coronary artery followed by reperfusion, with assessments conducted using ultrasound and microscopy to measure blood flow and tissue structure.
- - Findings revealed that endothelial damage and problems with blood vessel dilation were linked to the duration of blood flow interruption, with varying recovery patterns observed based on the length of the occlusion.
[Quantitative evaluation of canine renal blood flow with contrast-enhanced ultrasound].
Di Yi Jun Yi Da Xue Xue Bao
April 2005
Objective: To evaluate the accuracy of contrast-enhanced ultrasound (CEU) in renal blood flow quantification.
Methods: Regional renal perfusion was quantified with CEU in 10 dogs at the baseline level and after treatment with 3 doses of dopamine (3, 8 and 16 mg.kg(-1).
[Cardioprotective effects of K(ATP) channel opener nicorandil during ischemia/ reperfusion in dogs].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
March 2005
Objective: To further confirm the effect of nicorandil in reducing the area of myocardial infarct is through the mediation of activation of the KATP channel but not by its nitrate-like properties, and to determine whether the protective effect is the same or not when the drug is either given immediate after infarction or after reperfusion.
Methods: Thirty-five dogs were randomly divided into five groups as follows. Ischemia/reperfusion (IR) group: the dogs were subjected to 90 minutes of left anterior descending coronary artery(LAD) occlusion followed by 120 minutes reperfusion.