Publications by authors named "Ch Singer"
Background: The ABCSG-28 trial compared primary surgery followed by systemic therapy versus primary systemic therapy without surgery in patients with de novo stage IV BC. The present report describes QoL results of this trial.
Methods: Ninety patients with primary operable MBC were randomised to surgery of the primary tumor followed by systemic therapy or to primary systemic therapy without surgery.
Article Synopsis
- Recent studies suggest a connection between the overexpression of COX-2, p16, and Ki67 and the likelihood of developing invasive carcinoma in patients previously treated for ductal carcinoma in situ (DCIS).
- This study aims to investigate the correlation of COX-2, p16, and Ki67 expression levels across different breast cancer stages, including pure DCIS, microinvasive cancer (T1mic), and invasive ductal carcinoma with extensive intraductal components (EIC).
- Findings indicate significant differences in p16 expression among the tumor types, with the highest expression observed in the DCIS group, highlighting the potential prognostic value of these markers in assessing cancer progression.