[Validation of paternity in a father-mother-child trio, by the use of genetic markers. Description of a program to aid in the decision. Determination of the optimal sequence of examinations].

The knowledge of human polymorphism provides aid to the decision for the diagnosis parenthood. This work gives an algorithm of paternity diagnosis on a (presumed father, mother, child) triplet: the program verifies the logical relationships and calculates several indices used to estimate the likelihood of non-exclusion. We propose to attach greater importance to a neglected index: the percentage of subjects for which the paternity is excluded for the doublet (Mother, Child).

Antigen site distribution among weak A' red cell populations. A study of A3, Ax and Aend variants.

The distribution of the A receptors was studied among 'agglutinated' and 'free' populations of A variant RBC (A3, AX, Aend) known to be either partially or weakly agglutinated by human anti-A reagents. Following separation of the red cell populations and disaggregation of the clumps by mild treatment with soluble blood group substances, it was shown after appropriate controls, that among A3 ARBC, the 'agglutinated' RBC have at least five times as 'free' RBC, these latter however being strongly A positive. The differences between the A antigenic content of the AX RBC were less pronounced.