Cholinergic responses of ileal longitudinal muscle under short-lasting exposure to cupric ions.

1 The effect of short-term exposure to cupric ions (Cu2+) on electric field-stimulated (EFS) or agonist-induced contractions of guinea-pig isolated ileum was studied. 2 EFS elicited tetrodotoxin- and atropine-sensitive contractions that were concentration dependently inhibited by Cu2+ (IC50 = 14.7 +/- 4.

Time-related heart autonomic balance characteristics in healthy subjects.

Changes of the heart autonomic balance between morning (8-9 h) and afternoon (14-15 h) measurements were studied in 22 healthy subjects. The selection of these two daytime periods was substantiated by the established higher risk of cardiovascular incidents in the morning and the relative balance of the vegetative nervous system in the afternoon hours. The changes were analysed by RR-variability indices from ECG recordings in the resting state and with vegetative nervous system stimulation by the handgrip test and Valsalva manoeuvre.

[Studies on restraint ulcers in rats in conditions of acute copper deficiency].

In the present experiment, we have investigated the impact of the acute copper deficiency on the pathogenesis of stress ulcers' formation in rats during cold-restraint stress. A powdered milk diet, lasting for 5 days, causes a significantly decrease of stomach copper content in rat, comparing to content in rats receiving standard laboratory diet. The severity of mucosal disturbances, expressed as total number and area of stress ulcers, is most prominent in animals receiving hypocupric diet.

[The effect of the zinc-containing preparation Oxyrich in the treatment of chronic saturnism (preliminary results)].

Under indoor conditions the effect of the Bulgarian zinc-containing preparation Oxyrich was studied in the treatment of 12 workers (males) with chronic saturnism. The preparation was orally administered in a dose of 150 mg (0.45 mmol Zn++) daily for 10 days in three equal receivings, after which three day antidotal therapy with CaNa2 EDTA was carried out according to the classic schedule.

[Crow-Fukase syndrome--the first case report in Bulgaria].

A case of a 53 years old woman with Crow-Fukase's syndrome, the first case diagnosed and described in Bulgaria, is presented. The patient presented with polyneuropathy (predominantly locomotor, better expressed in the legs and less expressed in the hands, with hyperproteinorachia), anasarca (peripherial edema, ascites, hydrothorax), skin changes (hyperpigmentations), endocrinopathy (transitory carbohydrate intolerance), dysglobulinemia, organomegaly (hepatomegaly).

[Ischemic heart disease--clinical, biochemical and immunobiological parallels].

In patients with various forms of ischemic heart disease the following indices were examined by radial immunodiffusion: alpha-1-acid glycoprotein, alpha-1-antitrypsin, haptoglobin, alpha-2-glycoprotein, beta-2-glycoprotein, immunoglobulin, C3 and C4 complement fractions. The changes in the serum glycoproteins during the acute phase of myocardial infarction are pointed out. The changes in the immunoglobulins and the complement fractions in patients with ischemic heart disease are discussed.

[Possible role of apometallothioneins].

A hypothesis is proposed admitting the participation of apometallothioneines (AMT) as a common link in the etiopathogenesis of hypertonic disease (HD) and some diseases with polygene heredity. The preconditions of the hypothesis are discussed (role of genetic disposition, external factors as salt, stress, tobacco smoking, alcohol, microelements--V and Cd and glucocorticoids in the origination of arterial hypertension). AMT homeostasis is discussed as well as the possible connection with the metabolism of Zn and Cu and Cu in organism.

[Clinical studies of celiprolol in the treatment of arterial hypertension].

The antihypertensive effect of the preparation celiprolol was studied in a double blind experiment versus acebutolol in 60 patients (30 males and 30 females), with an average age 40 years. Only patients with hypertonic diseases, stage I-II, according to WHO classification were included in the study. The treatment Lasted 4 weeks.

[Viskaldix in the treatment of arterial hypertension].

Viskaldix, a combination of Pindolol (Visken)--10 mg with Clopamide--5 mg, was administered to 15 patients with arterial hypertension. The follow up of the patients was according to a previous plan, the preparation administered according, to a schedule. In the determination of the stage of the disease, consideration was mainly given to the values of the diastolic pressure, measured in a lying position.

[Changes in the gonads and reproductive capacity of white rats after oral maneb poisoning].

Changes in the gonads and reproduction capacity of white rats following oral intoxication with maneb are studied. The preparation at doses 1/10, 1/50, 1/100 and 1/5000 LD50 is administered to the starting generation of white rats twice weekly. Changes in the gonads--biochemical, histological, histoenzymatic and electron microscopic--are established, as well as a capacity for reproduction of the starting I and II offspring.