Cell proliferation and DNA fragmentation (apoptosis) on FNABs of breast invasive ductal carcinomas and their relationship to clinicopathological variables and prognosis.

The purpose of this study was to investigate cell proliferation and apoptosis in ductal breast invasive carcinomas and their relationship to prognosis. Fifty cases, from the same number of operable female patients, were diagnosed cytologically on FNA biopsies as invasive ductal breast carcinomas and confirmed histologically after oncectomy. In the same cases, to evaluate the cell proliferation and apoptosis, the MIB1 and the TUNEL method were used respectively.