Molecular Assessment of Domain I of Apical Membrane Antigen I Gene in : Implications in Invasion, Taxonomy, Vaccine Development, and Drug Discovery.

Given its global morbidity and mortality rates, malaria continues to be a major public health concern. Despite significant progress in the fight against malaria, efforts to control and eradicate the disease globally are in jeopardy due to lack of a universal vaccine. The conserved short peptide sequences found in Domain I of apical membrane antigen 1 (PfAMA1), which are exposed on the parasite cell surface and in charge of invasion of host cells, make PfAMA1 a promising vaccine candidate antigen.