Emission-based sensing of cobalt (II) and vitamin B12 via a bis-indole derivative.

In this study, a bis-indole compound was synthesized, characterized by 1H NMR, Fourier transform infrared, and mass spectroscopic measurements and used as a selective and efficient probe for the spectrofluorimetric analysis of Co (II). The cobalt-induced quenching in the emission maximum at 567 nm was considered as the analytical signal in calibration studies. When encapsulated in a polymethyl methacrylate (PMMA) matrix, the bis-indole compound exhibited a limit of detection (LOD) of 3.

Evaluation of p(HEMA-co-NIPAM) hydrogels for removal of methylene blue from aqueous solution: isotherm, kinetic, and thermodynamic studies.

In this study, a novel adsorbent material, poly (2-hydroxyethyl methacrylate-co-N-isopropyl acrylamide) (p(HEMA-co-NIPAM) hydrogel, was synthesized for the purpose of removing methylene blue (MB) from aqueous media. The synthesis of hydrogel was carefully conducted, and its properties were thoroughly examined using techniques such as Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The adsorption experiments conducted revealed a remarkable affinity of p(HEMA-co-NIPAM) hydrogel towards MB.

Neural Network Modeling of AChE Inhibition by New Carbazole-Bearing Oxazolones.

Acetylcholine esterase (AChE) is one of the targeted enzymes in the therapy of important neurodegenerative diseases such as Alzheimer's disease. Many studies on carbazole- and oxazolone-based compounds have been conducted in the last decade due to the importance of these compounds. New carbazole-bearing oxazolones were synthesized from several carbazole aldehydes and p-nitrobenzoyl glycine as AChE inhibitors by the Erlenmeyer reaction in the present study.

Synthesis and Spectroscopic Properties of Carbazole-Oxadiazoles.

Four new carbazole-oxadiazole derivatives (3a-b, 6a-b) were prepared from the reaction of aromatic aldehydes and carbohydrazides which were synthesized from carbazole aldehydes namely 9-hexyl-9H-carbazole-3-carbaldehyde 1 and 4-(9H-carbazole-9-yl)benzaldehyde 4 and acid hydrazides. The structures of the new derivatives were confirmed by H-NMR and FT-IR. The optical properties such as maximum absorption and emission wavelengths (λ; nm), molar extinction coefficients (ε; cm M), Stoke's shifts (ΔλST; nm) and quantum yields (ϕF), of the carbazole-oxadiazole derivatives were declared in dichloromethane, toluene and tetrahydrofuran solutions.

Synthesis of new ibuprofen derivatives with their in silico and in vitro cyclooxygenase-2 inhibitions.

Cyclooxygenase-2 (COX-2) is one of the important targets for treatment of inflammation related diseases. In the literature, most of drug candidates are first synthesized and then their COX-2 inhibitory activities are tested by in vitro and in vivo experiments. However, synthesis of dozens of drug analogues without any interpretations on their inhibitory activity can result in loss of time and chemicals.