Evaluating the Impact of Buprenorphine on Depressive Symptoms Among Veterans with Chronic Pain.

Buprenorphine has demonstrated benefit for acute and chronic pain and various psychiatric disorders. However, many studies evaluating buprenorphine's effect on psychiatric conditions are not specific to the chronic pain population. This retrospective study was conducted to assess the impact of buprenorphine on depressive symptoms in patients with chronic pain at a Veterans Affairs healthcare facility.

Electron Spin Correlations: Probabilistic Description and Geometric Representation.

The electron spin correlation is shown to be expressible in terms of a bona fide probability distribution function with an associated geometric representation. With this aim, an analysis is presented of the probabilistic features of the spin correlation within the quantum formalism, which helps clarify the concepts of contextuality and measurement dependence. The dependence of the spin correlation on probabilities allows for a clear separation between system state and measurement context; the latter determines how the probability space should be partitioned in calculating the correlation.

Retrospective Cohort Study of Safety Outcomes Associated with Opioid Rotations to Buprenorphine.

The objective of this study was to understand the effect buprenorphine rotations have on respiratory risk and other safety outcomes. This was a retrospective observational study evaluating Veterans who underwent an opioid rotation from full-agonist opioids to buprenorphine products or to alternative opioids. The primary endpoint was change in the Risk Index for Overdose or Serious Opioid-induced Respiratory Depression (RIOSORD) score from baseline to six months post-rotation.

The Electromagnetic Vacuum Field as an Essential Hidden Ingredient of the Quantum-Mechanical Ontology.

This paper provides elements in support of the random zero-point radiation field (zpf) as an essential ontological ingredient needed to explain distinctive properties of quantum-mechanical systems. We show that when an otherwise classical particle is connected to the zpf, a drastic, qualitative change in the dynamics takes place, leading eventually to the quantum dynamics. In particular, we demonstrate that in parallel with the evolution of the canonical variables of the particle into quantum operators satisfying the basic commutator x^,p^=iℏ, also the field canonical variables are transformed, giving rise to the corresponding creation and annihilation operators a^†,a^, satisfying a^,a^†=1.

DMSO reduces the cytotoxicity of anticancer ruthenium complex KP1019 in yeast.

Low solubility in aqueous solutions is a significant limitation of the otherwise promising anticancer ruthenium complex KP1019. In laboratory studies, this challenge is often overcome by using DMSO to help drive the drug into solution. Since DMSO was previously shown to alter the bioactivity of platinum-based chemotherapeutics, here we examine DMSO's effects on KP1019.

Traditional management of diabetes in Pakistan: Ethnobotanical investigation from Traditional Health Practitioners.

Ethnopharmacological Relevance: The uses of anti-diabetic plants are well anchored in the traditional health care system of Pakistan. To the best of our knowledge, this is the first ethno-botanical study about the uses of plants for the treatment of diabetes. The aim of the study is to record indigenous knowledge on anti-diabetic plants from Traditional Health Practitioners (THPs) and diabetic patients.

A phytotherapeutic extract of Equisetum myriochaetum is not genotoxic either in the in vivo wing somatic test of Drosophila or in the in vitro human micronucleus test.

Equisetum myriochaetum is a Mexican plant used in folk medicine to treat kidney diseases and type 2 diabetes mellitus. The main constituents of the phytoextract are flavonol glycosides (kaempferol), phytoesterols and carbohydrates. In this study, phytotherapeutic extracts from Equisetum myriochaetum were investigated for genotoxicity in the in vivo wing spot test in Drosophila melanogaster and in the in vitro human micronucleus test.