Publications by authors named "Cesarius S Wahono"
Aim: This study evaluates the prevalence, risk factors, and quality of life of patients with knee osteoarthritis (OA) in the Indonesian population.
Method: A cross-sectional study of 3597 adults (≥ 18 years old) was conducted in 2023 involving 15 different cities in Indonesia. Knee OA was classified according to the clinical ACR criteria.
Aim: To investigate the correlation between T-cell senescence with the atherosclerosis markers in patients with systemic lupus erythematosus (SLE).
Methods: The study participants were 40 female SLE patients aged 18-45 years who met the 2019 EULAR/ACR criteria and 40 healthy individuals. The atherosclerosis markers were investigated using the Doppler ultrasonography examinations to measure the cIMT (carotid intima-media thickness) and flow-mediated dilation (FMD) and serological markers using soluble ICAM-1 and VCAM-1.
Article Synopsis
- The study examined the cutaneous manifestations of systemic lupus erythematosus (SLE) in 54 patients from a clinic in Malang, Indonesia, finding that 50% exhibited skin lesions.
- Key findings showed that subacute cutaneous lupus erythematosus (SCLE) and malar rash were common, with SCLE being linked to higher disease activity scores compared to patients without skin lesions.
- The research also highlighted associations between specific skin lesions (like SCLE and malar rash) and systemic symptoms, indicating that cutaneous manifestations are significant indicators of disease severity in SLE patients.
Background: Curcumin-piperine might synergise with vitamin D to induce clinical remission in patients with systemic lupus erythematosus (SLE).
Objective: To observe the improvement of patients with SLE clinically and the levels of inflammatory cytokines after receiving supplements of curcumin-piperine and cholecalciferol (Vitamin D3).
Methods: Forty-five female SLE patients were included in a three-month double-blind, randomized controlled trial.
Article Synopsis
- * Utilizing matching-adjusted indirect comparison (MAIC), the research found secukinumab to be significantly more effective (higher response rates) and cost-effective than adalimumab, golimumab, and infliximab at both 24 and 52 weeks post-treatment.
- * The results indicated that secukinumab led to substantial cost savings (up to 83% lower) while also providing better patient outcomes, suggesting it is a preferable treatment option for AS in the Indonesian healthcare context.
Background: Healthcare workers (HCWs) run a high risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The HCWs are prone to the SARS-CoV-2 infection in the hospital despite being fully vaccinated. The present study aimed to address the factors associated with the coronavirus disease 2019 (COVID-19) vaccine breakthrough among HCWs.
View Article and Find Full Text PDFThe purpose of this study was to observe the role of vitamin D levels with T helper 1 (Th1)-type cytokines, such as interferon γ (IFN-γ) and interleukin-12 (IL-12) efficacy, in those who had already received 2 injections of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccines (CoronaVac). We also observed if these cytokines played any significance in the CoronaVac effectiveness for preventing coronavirus disease 2019 (Covid-19) infection. One hundred ninety-four volunteers were monitored for 8 months upon receiving 2 inactivated SARS-CoV2 vaccination injections (CoronaVac, Sinovac Life Sciences).
View Article and Find Full Text PDFObjective: This study aimed to observe the association between the presence of hypertension with Covid-19 vaccine effectiveness among healthcare workers who received CoronaVac vaccination.
Methods: We conducted a prospective cohort study in Saiful Anwar General Hospital, Malang, Indonesia on 155 healthcare workers aged 18-59 years old who already received twice of the CoronaVac (Sinovac Life Science, Beijing, China) injection with 14-day intervals. Hypertension was diagnosed according to the 2020 International Society of Hypertension.
Objectives: Systemic lupus erythematosus (SLE) patients are predisposed to chronic immune activation, leading to accelerated immunosenescence. The aging of the immune system causes the T cells to express several senescence markers such as CD57 and KLRG1, which produce pro-inflammatory cytokine interferon γ (IFN-γ). Immunosenescence was associated with high morbidity and mortality in other diseases.
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- - This study investigates the link between vitamin D levels and the risk of coagulopathy (blood clotting issues) in COVID-19 patients.
- - Out of 50 hospitalized COVID-19 patients, 84% had low vitamin D levels, and those with thrombotic events exhibited significantly lower vitamin D levels.
- - The findings suggest that low vitamin D is a risk factor for increased D-dimer levels and overt disseminated intravascular coagulation (DIC) in these patients.
Introduction: One of the possible mechanisms that contribute to the development of anemia in systemic lupus erythematosus (SLE) is the presence of premature immunosenescence in SLE. This study aimed to observe the correlation between immunosenescence with anemia in SLE.
Methods: This research was a cross-sectional study with the subject was 60 women with SLE aged 16-45 years old.
Objectives: The aim of the study was to analyze the correlation between periodontitis severity in systemic lupus erythematosus (SLE) with CD4/CD8 lymphocytes ratio and cytomegalovirus gamma immunoglobulin (IgG CMV) level.
Materials And Methods: This is a descriptive study using a cross-sectional approach that included 93 subjects who were diagnosed with SLE in Rheumatology Department, Saiful Anwar Hospital, during 2017 to 2019. Periodontitis severity was assessed by periodontal Index (PI).
Aim: To assess the factors defining healthcare-seeking behavior of people with musculoskeletal pain in the urban community of Malang City, East Java, Indonesia.
Methods: A cross-sectional survey was performed in Malang City, East Java, Indonesia. In total, 2067 participants aged 16-93 years were interviewed.
Vitamin D deficiency has been associated with pathogenesis of autoimmune diseases including SLE; however, there were still lack of data about the effects of administration of vitamin D in immune regulation in SLE patients. The aim of this study was to investigate the effects of calcitriol/1,25(OH)2D3 on dendritic cells maturation and Th17 and Treg cells activation in SLE patients with hypovitamin D. The monocytes and lymphocytes of five SLE patients with hypovitamin D were divided into 4 groups, P0 (0 nM/control), P1 (1 nM), P2 (10 nM), and P3 (100 nM) as cultured samples.
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