Publications by authors named "Cesare Morgante"
Introduction: Consensus regarding the diagnostic cutoff values for cortisol responses to low-dose Cosyntropin testing (LDT) and its specific advantages over standard (high) dose test (HDT) in assessing the pituitary-adrenal axis in children is lacking.
Methods: In a retrospective study, patients who underwent sequential LDT and HDT were classified into two groups depending on the reason for testing: prolonged systemic glucocorticoid exposure (Group 1) or suspected hypothalamic-pituitary dysfunction (Group 2). Sensitivity and specificity analysis of varying cortisol levels during LDT in diagnosing ACTH deficiency (ACTHD) were calculated via the receiver operating characteristic curve (ROC) analysis against the reference diagnostic test HDT.
Article Synopsis
- - Growth hormone treatment has evolved from using pituitary-derived GH for specific cases of GH deficiency to recombinant human GH (rhGH), which is now approved for various disorders beyond just GH deficiency.
- - RhGH significantly helps improve short stature in GH-deficient patients and has positive effects on metabolic and bone health, with long-term safety studies showing encouraging results, particularly for those with isolated GHD.
- - New long-acting rhGH formulations are being developed to enhance adherence to treatment and lessen the burden on patients, while ongoing surveillance is needed for safety in higher doses or other clinical conditions.
Pediatric thyroid side effects of immune checkpoint inhibitors.
Trends Endocrinol Metab
September 2024
Immune checkpoint inhibitors (ICIs) are associated with multiple endocrine side effects, including thyroid disfunctions. In addition, the efficacy and safety profiles of ICIs in the pediatric population need clarification. Here, we discuss the main evidence regarding the efficacy and thyroid toxicities of ICIs in children.
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- - Ganglioneuromas are rare tumors that usually develop in areas like the abdomen and adrenal glands, but this case involves a four-year-old girl with a neck mass initially thought to be a thyroid issue.
- - Lab tests showed normal hormone levels, and an ultrasound indicated a large mass from the left thyroid, leading to a fine needle biopsy that confirmed a benign neurogenic lesion.
- - After the patient had successful surgery to remove the mass, the histological examination confirmed it was a ganglioneuroma, and the case highlights important diagnostic details for rare neck tumors.
Plurihormonal (TSH-GH-prolactin Secreting) PIT-1-Positive pituitary Macroadenoma/Pituitary Neuroendocrine Tumor (PitNET) Associated with Graves' Disease: A Case Report.
Endocr Metab Immune Disord Drug Targets
September 2023
Article Synopsis
- A 58-year-old woman, with a history of Graves' disease, experienced symptoms of thyrotoxicosis, facial changes, headaches, and enlarged hands and feet over a year.
- Biochemical tests revealed elevated levels of thyroid hormones and significant increases in growth hormone, indicating the presence of a large pituitary tumor.
- The patient underwent successful surgery to remove the tumor, which was diagnosed as a plurihormonal pituitary adenoma, and her pituitary function returned to normal afterward.