Teaching in the Suburbs: Participatory Action Research Against Educational Wastage.

If teaching is a stressful job, it can be even more so in schools in disadvantaged areas, such as the metropolitan suburbs, where the rates of educational wastage are high. Here, teachers often feel ineffective: as a result, there is a reduced sense of well-being at work, which triggers a negative cycle that damages their educational performance. From the literature, it is known that teachers need social support, which has a positive effect on well-being and resilience.

Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells.

Background: Calcimimetics, such as R-568, are thought to activate G protein-linked Ca(2+)-sensing receptor (CaSR) by allosterically increasing the affinity of the receptor for Ca(2+) allowing for efficient control of uremic hyperparathyroidism. Several recent studies suggest they possess additional vascular actions. Although it has been postulated that calcimimetics may have a direct effect on CaSR in the blood vessels, further studies are needed to elucidate their vascular CaSR-dependent versus CaSR-independent effects.

Plasma protein carbonylation in chronic uremia.

Background: Carbonylation is an irreversible modification caused by the introduction into proteins of carbonyl derivatives (aldehydes and ketones), which can alter protein structure and function and lead to cellular dysfunction and tissue damage. Chronic uremia may be associated with an increased carbonyl overload ("carbonyl stress"), though carbonyl formation has been proposed so far for major plasma proteins only. In this study we looked for evidence and for the targets of plasma protein carbonylation in patients on hemodialysis.

Proteomics characterization of protein adsorption onto hemodialysis membranes.

Protein-adsorptive properties are a key feature of membranes used for hemodialysis treatment. Protein adsorption is vital to the biocompatibility of a membrane material and influences membrane's performance. The object of the present study is to investigate membrane biocompatibility by correlating the adsorbed proteome repertoire with structural feature of the membrane surfaces.