Publications by authors named "Cesare Casadei"
Article Synopsis
- Motorized spiral enteroscopy (MSE) is a new and advanced medical technique used to examine the intestines using special devices.
- However, it was withdrawn from the market because of safety concerns, particularly related to injuries in the throat, even though it showed good results in helping doctors diagnose and treat problems.
- A study in Italy aimed to test MSE's effectiveness and safety but had to stop early when the technique was removed from use; the study found that MSE could still be useful as a backup method if other techniques fail.
: Double-balloon enteroscopy (DBE) is a well-established procedure for direct visualisation of the entire small bowel mucosa, and, in contrast with other imaging techniques, allows to perform biopsies and therapeutic interventions. The aim of this study was to evaluate the indications, diagnostic yield, therapeutic yield, and complications of DBE in a cohort of consecutive patients according to patients' age. : We conducted a retrospective study of consecutive patients who underwent DBE in our endoscopy unit between January 2006 and December 2021.
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- Oncostatin M is a helpful blood marker that can show how well certain medicines work for people with inflammatory bowel diseases (IBD), especially when using anti-TNF drugs like infliximab.
- The study looked at two groups of IBD patients to see how well their treatment worked after 54 weeks, measuring oncostatin M and other markers in their blood and stool.
- Results showed that lower levels of oncostatin M before treatment were linked to better healing in patients taking anti-TNF drugs, but not in those on vedolizumab, indicating that oncostatin M is useful for predicting treatment success with anti-TNF medications.
Background/goal: Ulcerative colitis (UC) is characterized by chronic inflammation and progressive course, with potential extraintestinal complications including cardiovascular mortality. Serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels have been recently recognized as biomarkers of low-grade inflammation and cardiovascular disease. The aim of our study was to evaluate PCSK9 levels in patients with UC and different degrees of disease activity.
View Article and Find Full Text PDFBackground: Current literature still lacks studies evaluating the effectiveness and safety of switching from Infliximab originator to SB2 biosimilar in Inflammatory Bowel Diseases (IBDs). We aimed to verify the ability of SB2 to maintain the clinical and biochemical response induced by originator after switching. As secondary outcome, we aimed to verify safety, tolerability and immunogenicity of SB2 biosimilar compared with its IFX originator.
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- A study was conducted on the effectiveness and safety of Adalimumab (ADA) biosimilars, ABP501 and SB5, in patients with inflammatory bowel diseases (IBDs) who switched from the ADA originator.
- Data from 80 patients (55 on ABP501 and 25 on SB5) were compared to a control group of 38 patients continuing ADA for two years.
- Results indicated that both biosimilars maintained clinical and biochemical stability similar to the originator, with some patients needing additional steroids, but overall, they appear effective and safe, warranting further research.
Background: Faecal microbiota transplantation (FMT) is a reasonable therapeutic option for the treatment of infection (CDI) recurrent and refractory (RCDI) to therapy, but little evidence on the long-term impact of this therapy is currently available in the literature. The aim of this study was to evaluate the efficacy and safety of FMT in recurrent and refractory CDI and the modifications of the recipient's gut microbiota in the medium-long term.
Methods: This prospective study collects the clinical and laboratory data of RCDI patients treated with FMT by colonoscopy from February 2016 to October 2019.