Involvement of protein kinase C and not of NF kappa B in the modulation of macrophage nitric oxide synthase by tumor-derived phosphatidyl serine.

Nitric oxide (NO) is one of the main cytotoxic effector molecules involved in the killing of tumor cells by macrophages. In macrophages, lipopolysaccharide (LPS) alone or in combination with IFN-gamma causes the generation of NO by an inducible form of NO synthase (iNOS). We have previously reported that macrophages from mammary tumor bearers have a downregulation of their NO production leading to a diminished cytotoxic activity.

Healing pressure ulcers with collagen or hydrocolloid: a randomized, controlled trial.

Objectives: To compare the effects of topical collagen and hydrocolloid on pressure ulcer healing.

Design: Randomized (allocation concealed), single-blind (outcome assessors), controlled trial with 8-week follow-up.

Setting: Eleven nursing homes in central Illinois.