Publications by authors named "Cesar J Enriquez-Rodriguez"
Article Synopsis
- * An analysis of plasma samples from 40 COPD patients revealed 363 proteins, with 31 showing significant differences in levels between those who survived and those who did not after four years.
- * The study found that predictive models based on proteomic data achieved high accuracy for mortality prediction (90%) and suggested that specific protein groups related to immune response, hemostasis, and inflammation could enhance prognostic capabilities for managing COPD.
Although Chronic Obstructive Pulmonary Disease (COPD) is highly prevalent, it is often underdiagnosed. One of the main characteristics of this heterogeneous disease is the presence of periods of acute clinical impairment (exacerbations). Obtaining blood biomarkers for either COPD as a chronic entity or its exacerbations (AECOPD) will be particularly useful for the clinical management of patients.
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- The study aimed to compare the systemic proteomic profiles of frequent exacerbators (FE) and non-frequent exacerbators (NFE) among COPD patients, alongside a reference group of healthy controls (HC) and patients during an exacerbation (AE).
- Analysis included 40 stable COPD patients (20 FE and 20 NFE), and results showed 40 different proteins in FE, 10 in NFE, and 63 in AE compared to HC.
- Results indicated that FE patients had specific inflammatory dysregulations, with some proteomic changes shared with AE, while others were unique to exacerbation episodes.
COPD is a heterogeneous disorder that shows diverse clinical presentations (phenotypes and "treatable traits") and biological mechanisms (endotypes). This heterogeneity implies that to carry out a more personalised clinical management, it is necessary to classify each patient accurately. With this objective, and in addition to clinical features, it would be very useful to have well-defined biological markers.
View Article and Find Full Text PDFPatients with advanced chronic liver disease (ACLD) or cirrhosis undergoing surgery have an increased risk of morbidity and mortality in contrast to the general population. This is a retrospective, observational study to evaluate the predictive capacity of surgical risk scores in European patients with ACLD. Cirrhosis was defined by the presence of thrombocytopenia with <150,000/uL and splenomegaly, and AST-to-Platelet Ratio Index >2, a nodular liver edge seen via ultrasound, transient elastography of >15 kPa, and/or signs of portal hypertension.
View Article and Find Full Text PDFThe clinical presentation of chronic obstructive pulmonary disease (COPD) is highly heterogeneous. Attempts have been made to define subpopulations of patients who share clinical characteristics (phenotypes and treatable traits) and/or biological characteristics (endotypes), in order to offer more personalized care. Assigning a patient to any of these groups requires the identification of both clinical and biological markers.
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