Improvement in Kidney Function after Discontinuation of Fenofibrate in Outpatient Nephrology Consultation for Chronic Kidney Disease.

Background: It has been noted in observational and interventional studies that individuals exposed to fenofibrate can exhibit a rise in serum creatinine (sCr) concentration. However, it is not known to what extent this phenomenon impacts kidney function in patients who are referred to a nephrology clinic for consultation for chronic kidney disease (CKD).

Methods: We conducted a prospective observational study of patients referred to our nephrology clinic for a new evaluation of a rise in sCr or worsening CKD and who were on fenofibrate therapy.

AKI and Collapsing Glomerulopathy Associated with COVID-19 and High-Risk Genotype.

Background: Kidney involvement is a feature of COVID-19 and it can be severe in Black patients. Previous research linked increased susceptibility to collapsing glomerulopathy, including in patients with HIV-associated nephropathy, to apo L1 () variants that are more common in those of African descent.

Methods: To investigate genetic, histopathologic, and molecular features in six Black patients with COVID-19 presenting with AKI and nephrotic-range proteinuria, we obtained biopsied kidney tissue, which was examined by hybridization for viral detection and by NanoString for COVID-19 and acute tubular injury-associated genes.

Acute Kidney Injury Associated with Coronavirus Disease 2019 in Urban New Orleans.

Background: AKI is a manifestation of COVID-19 (CoV-AKI). However, there is paucity of data from the United States, particularly from a predominantly black population. We report the phenotype and outcomes of AKI at an academic hospital in New Orleans.