[Evaluation of susceptibility of multidrug-resistant Pseudomonas aeruginosa strains against ceftolozane/tazobactam].

Background: Pseudomonas aeruginosa is an opportunistic pathogen associated with high morbidity and mortality. For multidrug-resistant strains (MDR), ceftolozane/tazobactam (CTZ) has been authorized by the European Medicines Agency (EMA) for complicated urinary tract infections, acute pyelonephritis, and complicated intraabdominal infections.

Aim: To determine the susceptibility to CTZ of P.

A modified ESBL Nordmann/Dortet/Poirel-based protocol to optimize early sepsis management.

We evaluated a modification of a colorimetric test recently described by Dortet et al. (2015) for the rapid detection of ESBL-producing Enterobacteriaceae directly from positive blood cultures that requires less manipulation, materials and hands-on time. The simplified protocol showed a sensitivity and specificity of 100% and 95.