Obstetric Anal Sphincter Injury and Female Sexual Dysfunction: A Systematic Review.

Importance: This is the first systematic review on female sexual dysfunction (FSD) in patients who sustained obstetric anal sphincter injury (OASI).

Objective: The aim of the study was to characterize FSD following OASI.

Study Design: Between January and April 2024, we conducted a literature search of studies that explored outcomes of FSD following OASI, reporting on rates of dyspareunia and/or using questionnaires that measured female sexual function.

Genetic evaluation of udder health traits in Spanish Holstein cows.

The aims of this study were to estimate the genetic parameters of clinical mastitis (CM) and SCS traits, and to compare the performance of genetic evaluations of CM traits using univariate and bivariate analyses (CM-SCS). Data were edited according to the Udder Health Golden Standard harmonization, and then 6 CM traits and 6 SCS traits were considered, as the result of combining 3 lactation classifications (1, 2, ≥3) and 2 milking periods (early, late). The linear mixed animal models included the ratio of period at risk as a covariate, herd-year of calving, month of calving, and lactation-age as fixed effects, and the permanent environmental effect for traits of ≥3 lactations.

Analysing the pedigree to identify undesirable losses of genetic diversity and to prioritize management decisions in captive breeding: a case study.

When prevention of species extinction is the priority, captive breeding is a key component in conservation programmes, allowing the recording of pedigree information in studbooks. The genealogical information registered in Cuvier's gazelle studbook between 1975 and 2023 was analysed to (a) assess if the implemented mating policy was successful in preserving the genetic background of the founders (1 male:3 females) in the present population, and b) improve future management and breeding decisions. Although the maternal contribution of one founder female was lost and the mean inbreeding of the total live population was high (0.

Pedigree analysis in the mhorr gazelle (): Genetic variability evolution of the captive population.

Breeding programs have an essential role in the recovery of threatened populations through optimal genetic management and mating strategies. The dama gazelle () is a North African ungulate listed as critically endangered. The subspecies is extinct in the wild and currently survives thanks to the creation in 1971 of an ex situ breeding program.

Genomic inbreeding measures applied to a population of mice divergently selected for birth weight environmental variance.

This study aimed to compare different inbreeding measures estimated from pedigree and molecular data from two divergent mouse lines selected for environmental birth weight during 26 generations. Furthermore, the performance of different approaches and both molecular and pedigree data sources for estimating were tested in this population. A total of 1,699 individuals were genotyped using a high-density genotyping array.

Differential patterns in runs of homozygosity in two mice lines under divergent selection for environmental variability for birth weight.

Runs of homozygosity (ROH) are defined as long continuous homozygous stretches in the genome which are assumed to originate from a common ancestor. It has been demonstrated that divergent selection for variability in mice is possible and that low variability in birth weight is associated with robustness. To analyse ROH patterns and ROH-based genomic inbreeding, two mouse lines that were divergently selected for birth weight variability for 26 generations were used, with: 752 individuals for the high variability line (H-Line), 766 individuals for the low variability line (L-Line) and 74 individuals as a reference population.

Differential sensitivity of climate conditions on birth weight genetic values in mice divergently selected for birth weight residual variance.

After 32 generations of a divergent selection experiment for residual variance of birth weight in mice, two divergent lines were thus obtained: the heterogeneous line (H-line) and the homogeneous line (L-line). Throughout the generations, differences were observed between the two lines in traits such as litter size, survival at weaning, and birth weight variability caused by unidentified environmental conditions. The L-line exhibited advantages in terms of higher survival rates, larger litter sizes, and less sensitivity to changes in food intake.

Embryo survival and fertility differ in lines divergently selected for birth weight homogeneity in mice.

The selection of animals for lower environment sensitivity around the optimum trait value can also provide benefits in productivity and welfare. A divergent selection experiment for birth weight environmental variability in mice was successfully conducted over 17 generations. Animals from low variability selected line (L-line) were more robust by having a higher litter size and survival at weaning in a common breeding environment, than those from high variability line (H-line).

Genetic parameters for fleece uniformity in alpacas.

Fiber diameter is the main selection objective and criterion in alpaca breeding programs, but it can vary across anatomic regions of the animal. As fiber diameter is usually registered from a unique sample from the mid side of the body, fiber diameter variability within fleece is never addressed and phenotypic and genetic differences may exist for fleece uniformity in alpaca populations. The objective of this work was to estimate the genetic parameters of fleece uniformity in an alpaca population.

Fine-tuning genomic and pedigree inbreeding rates in equine population with a deep and reliable stud book: the case of the Pura Raza Española horse.

Background: Estimating inbreeding, which is omnipresent and inevitable in livestock populations, is a primary goal for management and animal breeding especially for those interested in mitigating the negative consequences of inbreeding. Inbreeding coefficients have been historically estimated by using pedigree information; however, over the last decade, genome-base inbreeding coefficients have come to the forefront in this field. The Pura Raza Española (PRE) horse is an autochthonous Spanish horse breed which has been recognised since 1912.

Methods for conducting trends analysis: roadmap for comparing outcomes from three national HIV Population-based household surveys in Kenya (2007, 2012, and 2018).

Background: For assessing the HIV epidemic in Kenya, a series of independent HIV indicator household-based surveys of similar design can be used to investigate the trends in key indicators relevant to HIV prevention and control and to describe geographic and sociodemographic disparities, assess the impact of interventions, and develop strategies. We developed methods and tools to facilitate a robust analysis of trends across three national household-based surveys conducted in Kenya in 2007, 2012, and 2018.

Methods: We used data from the 2007 and 2012 Kenya AIDS Indicator surveys (KAIS 2007 and KAIS 2012) and the 2018 Kenya Population-based HIV Impact Assessment (KENPHIA 2018).

Impact of selection for birth weight variability on reproductive longevity: A mice model.

Uniformity, understood as a similar performance in relevant livestock traits, such as birth weight within the litter, is being included as one of the selection objectives in breeding programmes, especially for polytocous livestock species. A divergent selection experiment for birth weight within-litter variability in mice during 23 generations showed that homogeneous animals were better for litter size, survival and feed efficiency but less heavy than heterogeneous animals. The aim of this study was to compare the reproductive longevity in both divergent lines as time to the end of the reproductive period.

Impact of the event effect in genetic evaluation for ranking traits in horses.

In genetic evaluation of horses, the genetic trend does not correspond into a phenotypic trend when using ranking as a phenotype due to its uniform distribution, and some other effects might be absorbing that trend. From a founder population, a further four discrete generations of 100 individuals were simulated under random mating. Then, ten additional discrete generations were simulated by selecting the best 10% of the animals.

Colorimetry analysis of coat color and its relationship with fiber traits in alpacas.

Addressing the improvement of the textile characteristics is currently required in natural color production of alpaca fiber. This study analyses the possibility of implementing a genetic improvement program aiming to reduce the fiber diameter and the percentage of medullation in natural colors under the incomplete definition of the natural colors of alpaca fiber. The study considers color determination analysis in three separate steps.

Breeding Strategies to Optimize Effective Population Size in Low Census Captive Populations: The Case of .

Small-sized animal populations can undergo significant loss of genetic variability that can lead to their extinction. Therefore, studies on animal breeding have focused on mating systems for minimizing the disappearance of genetic variability. The main objective of this study was to compare, using computer simulations, the performance of different breeding schemes to limit the loss of genetic diversity in small-sized populations.

Genetic parameters for uniformity of harvest weight in Pacific white shrimp (Litopenaeus vannamei).

Background: Uniformity of body weight is a trait of great economic importance in the production of white shrimp (Litopenaeus vannamei). A necessary condition to improve this trait through selective breeding is the existence of genetic variability for the environmental variance of body weight. Although several studies have reported such variability in other aquaculture species, to our knowledge, no estimates are available for shrimp.

Genetic parameters for canalization analysis of morphological traits in the Pura Raza Español horse.

Measurements from 13 different morphological traits of importance in the Pura Raza Español (PRE) horse were used to estimate genetic and environmental parameters following a heteroscedastic model in which data were assigned to stallions. Data sets used ranged from 20,610 (height at withers) to 48,486 measurements (length of shoulder), and the number of animals analysed in the pedigrees varied from 17,662 (height at withers) to 23,962 (dorsal-sternal diameter). Results of heritabilities of the traits varied from 0.

Combining Threshold, Thurstonian and Classical Linear Models in Horse Genetic Evaluations for Endurance Competitions.

The racing time and rank at finish traits are commonly used for endurance horse breeding programs as a measure of their performance. Even so, given the nature of endurance competitions, many horses do not finish the race. However, the exclusion of non placed horses from the dataset could have an influence on the prediction of individual breeding values.

Selection Response in a Divergent Selection Experiment for Birth Weight Variability in Mice Compared with a Control Line.

Birth weight (BW) in animal production is an economically important trait in prolific species. The laboratory mouse ( ) is used as an experimental animal because it is considered a suitable model for prolific species such as rabbits and pigs. Two mouse lines were divergently selected for birth weight variability with a third line of non-selected control population of the same origin as the animals starting the experiment.

Challenging the selection for consistency in the rank of endurance competitions.

Background: Control of the environmental variability by genetic selection offers possibilities for new selection objectives for productive traits. This methodology aims at reducing heterogeneity in productive traits and has been applied to several traits and species for which animal homogeneity is profitable. In horse breeding programmes, rank in competitions is a common selection objective but has been challenging to model.

Phenotypic and genetic analysis of reproductive traits in horse populations with different breeding purposes.

Reproductive traits have a major influence on the economic effectiveness of horse breeding. However, there is little information available. We evaluated the use of reproductive traits as selection criteria in official breeding programs to increase the reproductive efficiency of breeding studs, analysing 696 690 records from the pedigree data of eight Spanish horse populations, with different breeding purposes.

The Statistical Scale Effect as a Source of Positive Genetic Correlation Between Mean and Variability: A Simulation Study.

The selection objective for animal production is the highest income with the lowest production cost, while ensuring the highest animal welfare. A selection experiment for environmental variability of birth weight in mice showed a correlated response in the mean after 20 generations starting from a crossed panmictic population. The relationship between the birth weight and its environmental variability explained the correlated response.

Effect of feed restriction on the environmental variability of birth weight in divergently selected lines of mice.

Background: Selection of mice for decreased environmental variability of birth weight has achieved higher survivability and larger litter size as a correlated response to canalized selection, which suggests higher welfare and robustness, and animals that are more homogeneous. However, in these studies, animals were not exposed to an environmental challenge. To demonstrate the advantages of this mouse line with a low environmental variability of birth weight, animals from two divergent lines (high and low variability of birth weight) were subjected to feed restriction.

Genetic parameters for medullated fiber and its relationship with other productive traits in alpacas.

The alpaca fiber diameter (FD) varies from 18 to 36 μm, being the finer fiber categories highly appreciated. However, the alpaca fiber presents some limitations in the textile industry due to the high incidence of fiber medullation and diameter variability, both reduces the comfort feeling of the garments. Decreasing or even removing medullation could be a possible selection objective in alpaca breeding programs for increasing economic value of the alpaca fiber.