Publications by authors named "Ceren Alis"

Article Synopsis
  • The study investigates the high prevalence of pain in Parkinson's disease (PD) patients, with 80.6% reporting pain, indicating its significant impact on quality of life.
  • It distinguishes between neuropathic pain (NP) and musculoskeletal pain, finding that longer disease duration predicts NP and that females experience more musculoskeletal pain.
  • The research highlights the correlation between anxiety and central parkinsonian pain and suggests further exploration of amantadine's potential benefits in managing pain, emphasizing the need for personalized treatment approaches in PD.
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Objective: We studied blink reflex (BR) and BR excitability recovery (BRER) in patients with hemifacial spasm (HFS) exhibiting different abnormal discharge patterns. We hypothesized that patients with groups of clonic or tonic burst activities appear later in the disease course and may have more excitability of the BR circuit at the brainstem compared to patients with isolated twitchings, which occur earlier.

Methods: We included 124 patients with botulinum toxin-naive HFS (mean age 50.

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The use of deep learning (DL) techniques for automated diagnosis of large vessel occlusion (LVO) and collateral scoring on computed tomography angiography (CTA) is gaining attention. In this study, a state-of-the-art self-configuring object detection network called nnDetection was used to detect LVO and assess collateralization on CTA scans using a multi-task 3D object detection approach. The model was trained on single-phase CTA scans of 2425 patients at five centers, and its performance was evaluated on an external test set of 345 patients from another center.

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Background: Lesional posterior cortex epilepsy (PCE) is often drug resistant and may benefit from surgical intervention. In this study, we aimed to identify potential predictive factors associated with seizure recurrence after epilepsy surgery in lesional PCE.

Methods: We retrospectively reviewed patients with PCE who underwent surgery between 1998 and 2021.

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Article Synopsis
  • The study investigates the use of F-FDG PET/MRI combined with EEG to analyze the metabolic patterns in patients with gray matter heterotopia (GMH) and epilepsy.
  • The research involved 30 patients, evaluating the metabolism of heterotopic nodules and identifying the epileptogenic zone (EZ) through imaging and clinical methods.
  • Results showed varied metabolic activity in heterotopic nodules, with a strong correlation between imaging findings and the clinical EZ in most cases, indicating the significance of F-FDG PET/MRI in epilepsy assessment.
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To investigate the performance of a joint convolutional neural networks-recurrent neural networks (CNN-RNN) using an attention mechanism in identifying and classifying intracranial hemorrhage (ICH) on a large multi-center dataset; to test its performance in a prospective independent sample consisting of consecutive real-world patients. All consecutive patients who underwent emergency non-contrast-enhanced head CT in five different centers were retrospectively gathered. Five neuroradiologists created the ground-truth labels.

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Objective: The aim of this study was to evaluate patients who were hospitalized with a diagnosis of COVID-19 and were consulted by neurology during their hospital stay.

Methods: All files of patients with COVID-19 who were admitted to Cerrahpasa Medical Faculty Hospital between March 11th and December 31st, 2020 were retrospectively reviewed, and files of patients who consulted by neurology during their stay were included. Demographic and clinical characteristics, neurologic diagnosis, outcome and related laboratory data were extracted from electronic medical records and analyzed.

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There is little evidence on the applicability of deep learning (DL) in the segmentation of acute ischemic lesions on diffusion-weighted imaging (DWI) between magnetic resonance imaging (MRI) scanners of different manufacturers. We retrospectively included DWI data of patients with acute ischemic lesions from six centers. Dataset A (n = 2986) and B (n = 3951) included data from Siemens and GE MRI scanners, respectively.

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Purpose: Apneas are classified in three categories, as obstructive, central, and mixed types. Mixed apneas are calculated together with the obstructive events in diagnosing obstructive sleep apnea syndrome (SAS). The clinical significance of mixed apneas needs to be specified.

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Objective: In healthy subjects, there is a reduction in the amplitudes of somatosensory-evoked potentials (SEPs) after the simultaneous stimulation of two nerves compared to the sum of separate stimulations. This reduction is due to the inhibition of one area in the cortex after stimulation of the neighboring area, which results from the surround inhibition (SI) phenomenon. In this study, we aimed to investigate whether there was a decrease in SI of SEP in patients with juvenile myoclonic epilepsy (JME).

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We analysed the recovery function of somatosensory evoked potentials (SEPs) in juvenile myoclonic epilepsy (JME) patients. We hypothesized that there may be disinhibition in the recovery of SEPs at 20-100 ms intervals in JME patients. We recorded SEPs and SEP recovery in 19 consecutive patients with JME admitted for a routine follow-up examination, and in a control group composed of 13 healthy subjects who were similar to the patient group regarding age and sex.

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Aim: To evaluate apparent diffusion coefficient (ADC) characteristic of parenchymal neuro-Behçet's disease (NBD).

Methods: We retrospectively reviewed cranial magnetic resonance imaging (MRI) examinations of NBD patients with acute or chronic parenchymal lesions. ADC measurements of the lesions and contralateral normal brain parenchyma were performed by a consensus of two radiologists.

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Objectives: To assess lumbar multifidus muscle stiffness in patients with unilateral lumbar disk herniation (LDH) causing nerve root compression using shear wave elastography (SWE).

Methods: Thirty-three patients with unilateral subarticular LDH (L3-L4, L4-L5, and L5-S1) causing nerve root compression, diagnosed by magnetic resonance imaging, were enrolled in the study. Exclusion criteria were bilateral or multilevel LDH confirmed on magnetic resonance imaging, bilateral leg symptoms, and patients with a history of any spinal operation, malignancy, trauma, infection, spondylolisthesis, severe lateral recess stenosis, spinal canal stenosis, and substantial comorbidities.

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Synopsis of recent research by authors named "Ceren Alis"

  • - Ceren Alis's recent research focuses on the intersection of neurology and advanced imaging techniques, particularly in understanding conditions such as hemifacial spasm and epilepsy, as well as leveraging deep learning for diagnostic improvements in acute neurological conditions.
  • - Key findings from Alis include insights into blink reflex excitability in hemifacial spasm patients, predictive factors for seizure recurrence in lesional posterior cortex epilepsy, and the utility of deep learning for automated detection of large vessel occlusions and intracranial hemorrhage.
  • - The studies emphasize the importance of innovative technologies, including machine learning algorithms and neuroimaging methods, in enhancing diagnostic accuracy and treatment planning for various neurological disorders.

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