Accelerating pharmaceutical tablet development by transfer of powder compaction equipment across types and scales.

Roller compaction is a key unit operation in a dry granulation line for pharmaceutical tablet manufacturing. During product development, one would like to find the roller compactor (RC) settings that are required to achieve a desired ribbon solid fraction. These settings can be determined from the compression profile of the powder mixture being compacted and a mathematical model that interprets it.

Predicting drug solubility in organic solvents mixtures: A machine-learning approach supported by high-throughput experimentation.

A novel approach based on supervised machine-learning is proposed to predict the solubility of drugs and drug-like molecules in mixtures of organic solvents. Similar to quantitative structure-property relationship (QSPR) models, different solvent types are identified by molecular descriptors, which, in this study, are considered as UNIFAC subgroups. To overcome the potential lack of UNIFAC subgroups for the complex Active Pharmaceutical Ingredients (APIs) currently developed in the pharmaceutical industry, the API molecule is considered as a unique entity in the proposed modelling approach.

Efficacy and safety of a new low-volume PEG with citrate and simethicone bowel preparation for pediatric elective colonoscopy: Phase 3 RCT.

Currently available polyethylene glycol (PEG)-based preparations continue to represent a challenge in children. The aim of this study was to compare the efficacy and safety of a new low-volume PEG preparation with a conventional PEG-electrolyte solution (PEG-ES) in children and adolescents. This was a multicenter, randomized, observer-blind, parallel-group, phase 3 clinical trial, where patients were randomized between PMF104 (Clensia) and a conventional PEG-ES (Klean-Prep), and stratified by age stratum (2 to <6; 6 to < 12;12 to <18 years).

Streamlining tablet lubrication design via model-based design of experiments.

In oral solid dosage production through direct compression powder lubrication must be carefully selected to facilitate the manufacturing of tablets without degrading product manufacturability and quality (e.g. dissolution).

The Relationship Between Endoscopic and Clinical Recurrence in Postoperative Crohn's Disease: A Systematic Review and Meta-analysis.

Background And Aims: We aimed to quantify the magnitude of the association between endoscopic recurrence and clinical recurrence [symptom relapse] in patients with postoperative Crohn's disease.

Methods: Databases were searched to October 2, 2020, for randomised controlled trials [RCTs] and cohort studies of adult patients with Crohn's disease with ileocolonic resection and anastomosis. Summary effect estimates for the association between clinical recurrence and endoscopic recurrence were quantified by risk ratios [RR] and 95% confidence intervals [95% CI].

Differences in Shape in Organically Reared Chicken Lines Measured by Means of Geometric Morphometrics.

In the present study, the conformation of the of seven genetic lines of broilers was analyzed by Geometric Morphometrics and correlated to carcass weight and walking ability. The used chicken genetic lines were classified as fast, medium, or slow growing and ranked for their walking ability. Six chicken types were reared in an organic farm and slaughtered at 81 days of age while one slow-growing and highly walking line (Naked Neck) was reared in a commercial farm and used as external reference for moving activity and growth speed.

Antimalarial efficacy of piperaquine-based antimalarial combination therapies: facts and uncertainties.

Piperaquine is a bisquinoline antimalarial drug extensively used as monotherapy in China in the 1980s and subsequently included as one of the components of the artemisinin-based combination therapies (ACTs) in the 1990s. Among them, dihydroartemisinin-piperaquine (DHA-PQP) represents a new and extremely promising fixed combination. Several clinical trials have repeatedly shown that DHA-PQP is a safe and highly efficacious therapy against uncomplicated Plasmodium falciparum and the asexual stages of Plasmodium vivax malaria.

From the fetal liver to spleen and gut: the highway to natural antibody.

The film of sIgA lining the intestinal epithelium plays a role in the regulation of the commensal microflora and prevention of pathogen invasion. We show that, in the absence of intentional immunization, all sIgA in the gut is produced by B-1a B cells. We also show that B-1a B cells and sIgA derive from lineage-negative precursors found in the fetal liver and located in the spleen after birth.

Effects of condensed tannin from Acacia mearnsii on sheep infected naturally with gastrointestinal helminthes.

The effect of tannins on endoparasite control in hair sheep was investigated using 20 entire lambs of the Santa Inês breed. At the beginning of the experiment these animals were 6-months old and weighed 22.5kg+/-4.

The immunological effects of extracorporeal photopheresis unraveled: induction of tolerogenic dendritic cells in vitro and regulatory T cells in vivo.

Extracorporeal photopheresis (ECP) may represent an alternative to immunosuppression, as a means of reducing rejection after thoracic organ transplantation. The mechanism by which ECP exerts its protective effects has, until now, remained elusive. We analyzed peripheral blood mononuclear cells of four children with chronic heart and lung transplant rejection, who received ECP in addition to conventional immunosuppressive treatment.

Cellular re-distribution of flavin-containing polyamine oxidase in differentiating root and mesocotyl of Zea mays L. seedlings.

Plant polyamine oxidases (PAOs; EC 1.5.3.

Polyamine oxidase, a hydrogen peroxide-producing enzyme, is up-regulated by light and down-regulated by auxin in the outer tissues of the maize mesocotyl.

Exogenously supplied auxin (1-naphthaleneacetic acid) inhibited light-induced activity increase of polyamine oxidase (PAO), a hydrogen peroxide-producing enzyme, in the outer tissues of maize (Zea mays) mesocotyl. The same phenomenon operates at PAO protein and mRNA accumulation levels. The wall-bound to extractable PAO activity ratio was unaffected by auxin treatment, either in the dark or after light exposure.

[Radioisotope study of urinary deformity pathology in childhood].

The role of radionuclide investigation of urinary tract pathology in pediatric patients (computerized radionuclide urography and radionuclide cystogram) is discussed. Advantages of reliable morphological and functional study with a non invasive, low radiation procedure are emphasized.

[Hepatic hemangioma: limitations of echo-scintigraphic diagnosis].

The Authors report a case of percutaneous liver biopsy of a solitary hepatic lesion complicated by a serious haemorrhage. By a timely surgical operation an hepatic hemangioma has been detected. The lack of diagnostic accuracy of the echo-scintigraphic detection in assessing a solitary hepatic lesion is analyzed.