Relative bradycardia presented as a clinical feature of infection: A case report.

Brucellosis, caused by species, is an infectious disease transmitted through contact with infected animals or their secretions. The clinical disease is characterized by fever and headache. Relative bradycardia is an inappropriate response of heart rate to body temperature, in which the heart rate does not increase proportionally despite a high fever.

Selective Intramolecular Dehydrocyclization of Co-Porphyrin on Au(111).

The on-surface C-H bond activation and coupling reaction is a powerful approach to constructing fine-tuned surface nanostructures. It is quite challenging to control its regioselectivity due to the inertness of the C-H bond involved. With scanning tunneling microscopy/spectroscopy and theoretical calculations, the C-H activation and sequential intramolecular dehydrocyclization of -tetra(p-methoxyphenyl)porphyrinatocobalt(II) was explored on Au(111), showing that the methoxy groups in the molecule could kinetically mediate the selectivity of the intramolecular reaction over its intermolecular coupling counterpart.

Long noncoding RNA MALAT1 promotes high glucose-induced inflammation and apoptosis of vascular endothelial cells by regulating miR-361-3p/SOCS3 axis.

Vascular complications are the important pathophysiologic manifestations of patients with diabetes mellitus (DM) and many long non-coding RNAs (LncRNAs) are involved in this process. In this study, we aimed to investigate the relationships among LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), microRNA-361-3p (miR-361-3p), and suppressor of cytokine signaling 3 (SOCS3) in high glucose (HG)-induced human umbilical vein endothelial cell (HUVEC) injury and its underlying mechanism. We found that HG treatment significantly promotes MALAT1 and SOCS3 expressions, but inhibits miR-361-3p expression in HUVECs.

Reversibly Switching the Charge State and Adsorption Location of A Single Potassium Atom on Ultrathin CuO Films.

Potassium (K) cations are spontaneously formed upon thermal deposition of low-coverage K onto an ultrathin CuO monolayer grown on Cu(110) and they were explored by low-temperature scanning tunneling microscopy (STM) and X-ray photoemission spectroscopy. The formed K cations are highly immobile and thermally stable. The local work function around an individual K cation decreases by 1.

Changes of the acute and chronic toxicity of three antimicrobial agents to Daphnia magna in the presence/absence of micro-polystyrene.

The effects of microplastics on aquatic organisms are drawing growing attention, but little has been focused on their effects on the toxicity of other chemicals. In this study, we examined the acute and chronic toxicity of micro-polystyrene (5.8 μm dia.

Steering the Achiral into Chiral with a Self-Assembly Strategy.

Chirality transfer from self-assembly of achiral titanyl phthalocyanine (TiOPc) to its top-sitting TiOPc molecule has been successfully achieved. The TiOPc molecules first assemble into a porous network on Au(111) that contains periodic chiral voids, each being fenced by four axially rotating TiOPc molecules in upward adsorption geometry where their ending O atoms exclusively point away from the substrate. The additional top-sitting TiOPc molecule turns out to be chiral upon adsorption on a chiral void with its ending O atom toward the substrate.

Screening and separation of α-amylase inhibitors from Solanum nigrum with amylase-functionalized magnetic graphene oxide combined with high-speed counter-current chromatography.

A screening method using α-amylase-functionalized magnetic graphene oxide combined with high-speed counter-current chromatography was proposed and utilized to screen and separate α-amylase inhibitors from extract of Solanum nigrum. The α-amylase-functionalized magnetic graphene oxide was characterized and found to demonstrate satisfactory structure, magnetic response (24.5 emu/g), and reusability (retained 90% of initial activity after five cycles).

Predictive models for identifying the binding activity of structurally diverse chemicals to human pregnane X receptor.

Toxic chemicals entered into human body would undergo a series of metabolism, transport and excretion, and the key roles played in there processes were metabolizing enzymes, which was regulated by the pregnane X receptor (PXR). However, some chemicals in environment could activate or antagonize human pregnane X receptor, thereby leading to a disturbance of normal physiological systems. In this study, based on a larger number of 2724 structurally diverse chemicals, we developed qualitative classification models by the k-nearest neighbor method.

A chemist's overview of surface electron spins.

This review summarizes recent research progress in the measurement and tuning of the electron spins of alien atoms and molecules adsorbed on well-defined substrates. After a brief introduction to the main experimental techniques employed to study surface electron spins, some well-explored systems consisting of atomic and molecular spin-carriers at surfaces are overviewed from a chemist's viewpoint, focusing on the experimental measurements and chemical modifications of the electron spin states of the alien entities at the surfaces on the atomic/molecular level. Finally, personal perspectives have been provided, aiming at describing some of the remaining issues that need to be addressed in the future and proposing potential applications in surface chemistry.

Rapid Screening and Identification of BSA Bound Ligands from Radix astragali Using BSA Immobilized Magnetic Nanoparticles Coupled with HPLC-MS.

is widely used either as a single herb or as a collection of herbs in a complex prescription in China. In this study, bovine serum albumin functionalized magnetic nanoparticles (BSA-MN) coupled with high performance liquid chromatography-mass spectrometry (HPLC-MS) were used to screen and identify bound ligands from the -butanol part of a extract. The prepared BSA-MN showed sufficient magnetic response for the separation with an ordinary magnet and satisfied reusability.

Development of predictive models for predicting binding affinity of endocrine disrupting chemicals to fish sex hormone-binding globulin.

Disturbing the transport process is a crucial pathway for endocrine disrupting chemicals (EDCs) exerting disrupting endocrine function. However, this mechanism has not received enough attention compared with that of hormones receptors and synthetase. Recently, we have explored the interaction between EDCs and sex hormone-binding globulin of human (hSHBG).

Isolation of α-Amylase Inhibitors from Kadsura longipedunculata Using a High-Speed Counter-Current Chromatography Target Guided by Centrifugal Ultrafiltration with LC-MS.

In this study, a high-speed counter-current chromatography (HSCCC) separation method target guided by centrifugal ultrafiltration with high-performance liquid chromatography-mass spectrometry (CU-LC-MS) was proposed. This method was used to analyze α-amylase inhibitors from Kadsura longipedunculata extract. According to previous screening with CU-LC-MS, two screened potential α-amylase inhibitors was successfully isolated from Kadsura longipedunculata extract using HSCCC under the optimized experimental conditions.

Development of TLSER model and QSAR model for predicting partition coefficients of hydrophobic organic chemicals between low density polyethylene film and water.

Partition coefficients are vital parameters for measuring accurately the chemicals concentrations by passive sampling devices. Given the wide use of low density polyethylene (LDPE) film in passive sampling, we developed a theoretical linear solvation energy relationship (TLSER) model and a quantitative structure-activity relationship (QSAR) model for the prediction of the partition coefficient of chemicals between LDPE and water (K). For chemicals with the octanol-water partition coefficient (log K) <8, a TLSER model with V (McGowan volume) and qA (the most negative charge on O, N, S, X atoms) as descriptors was developed, but the model had relatively low determination coefficient (R) and cross-validated coefficient (Q).

Low-temperature scanning tunneling microscopy study on the electronic properties of a double-decker DyPc2 molecule at the surface.

To fully achieve potential applications of the double-decker molecules containing rare earth elements as single-molecule magnets in molecular spintronics, it is crucial to understand the 4f states of the rare earth atoms sandwiched in the double-decker molecules by metal electrodes. In this study, low-temperature scanning tunneling microscopy and spectroscopy were employed to investigate the isolated double-decker DyPc2 molecule adsorbed on Au(111) via its differential conductance measurements. The experimental results revealed that the differential conductance maps acquired at a constant height mode simply depicted the authentic molecular orbitals; moreover, the differential conductance maps achieved at a constant current mode could not directly probe the 4f states of the sandwiched Dy atom.

Analysis of α-amylase inhibitor from corni fructus by coupling magnetic cross-linked enzyme aggregates of α-amylase with HPLC-MS.

As a carrier-free immobilization strategy, magnetic cross-linked enzyme aggregates (MCLEAs) showed improved enzyme activity, stability and magnetic response. In this study, MCLEAs of α-amylase (MCLEAs-amylase) was prepared under optimized conditions and characterized with scanning electron microscope and vibrating sample magnetometer. The prepared MCLEAs-amylase showed an amorphous structure and the saturation magnetization was 33.

[Doxorubicin preconditioning instead of ischemic preconditioning in providing ischemic tolerance for rats abdomen island flaps].

Objective: To investigate the effects and mechanism of doxorubicin preconditioning in providing ischemic tolerance for rats abdomen island flaps.

Methods: Twenty-four healthy adult Sprague Dawley rats, 12 males and 12 females, were randomly divided into 3 groups (n = 8): control group (group A), ischemic preconditioning group (group B), and doxorubicin preconditioning group (group C). After the abdomen island flap (6 cm x 3 cm in size) based on the superficial inferior epigastric neurovascular bundle was prepared, group A had no further treatment; group B was given a 10-minute ischemia followed by a 10-minute reperfusion for 4 times; and group C was given pretreatment with doxorubicin (1 mg/kg) by injection of the inferior epigastric vein.