Cancer resistance and metastasis are maintained through oxidative phosphorylation.

Malignant tumors have increased energy requirements due to growth, differentiation or response to stress. A significant number of studies in recent years have described upregulation of mitochondrial genes responsible for oxidative phosphorylation (OXPHOS) in some tumors. Although OXPHOS is replaced by glycolysis in some tumors (Warburg effect), both processes can occur simultaneously during the evolution of the same malignancies.

Pectin hydrogels crosslinked via peptide nanofibers for designing cell-instructive dynamic microenvironment.

As has been reported many times before, the two-dimensional (2D) cell culture techniques used today are far from modeling native tissue environments. Therefore, tremendous amounts of effort were devoted to developing three-dimensional (3D) cell cultures with high tissue resemblance. Whereas, these techniques suffer from elaborate preparation processes, batch-to-batch variations, unnatural components, chemical modifications, side products, static culture conditions, or complex reactor systems.