The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults.

Background: The primary aim of this study was to compare the effects of a small-dose infusion of 2 antioxidant agents, ketamine and lidocaine, on ischemia-reperfusion injury (IRI) in patients undergoing elective lower limb surgery. Ischemia-modified albumin (IMA), lactate, and blood gas levels were all measured and assessed.

Methods: A total of 100 patients who underwent lower extremity surgery were randomized into 3 groups.