Publications by authors named "Cemal Bes"
CT-P13 is a biosimilar version of infliximab, a monoclonal antibody. In individuals with ankylosing spondylitis (AS), CT-P13 has been shown to be effective and to have a well-tolerated safety profile. The aim of this study was to evaluate the long-term drug persistence, safety, and efficacy of infliximab biosimilar CT-P13 in patients with AS undergoing first-line (1st-line) and later (≥2nd-line) treatment in clinical practice.
View Article and Find Full Text PDFClinical course of pediatric-onset Behçet's Disease in young adulthood.
Rheumatology (Oxford)
November 2024
Article Synopsis
- The study investigates the progression of Behçet's disease when it starts in childhood and how it affects patients in adulthood.
- Out of 112 pediatric patients, 93 were analyzed, revealing that around 52.5% had major organ involvement, primarily affecting the eyes, with some showing new complications as they transitioned into adulthood.
- The findings highlight the importance of continued monitoring for these patients, as nearly one-third experienced new symptoms or relapses post-childhood, underscoring the need for regular follow-ups to mitigate potential long-term damage.
Objectives: Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease affecting both genders in reproductive age. In this study, we aimed to investigate the relation between FMF and pregnancy on both maternal and fetal aspects.
Material And Methods: In this retrospective, single-center, descriptive study we analysed total of 95 pregnancies of 40 FMF patients.
Article Synopsis
- The study evaluated the combined arteritis damage score (CARDS) in Takayasu arteritis (TAK) patients to see how well it predicts the need for biologic treatment and the role of wall thickness (WT) in that prediction.* -
- Results indicated that patients requiring biologic treatment had significantly higher CARDS, WT, and modified CARDS (mCARDS) scores compared to those receiving non-biologic treatment, suggesting mCARDS is a strong predictor of treatment needs.* -
- The findings imply that using non-invasive angiographic imaging to assess CARDS and WT can enhance prognosis and inform treatment decisions for TAK patients, with mCARDS showing the best performance in sensitivity and specificity.*
Article Synopsis
- Behçet disease (BD) presents with various symptoms, including mucocutaneous, ocular, and vascular manifestations, and this study explores the immune-related cytokines involved in these different BD types.
- Researchers analyzed serum samples from active and remission stages of BD patients, comparing them with healthy controls, to evaluate the levels of specific cytokines like interferon γ and interleukin 35.
- The findings indicate distinct immune responses for each BD phenotype, particularly showing that the IL-17 response is less pronounced in ocular BD, suggesting a need for targeted treatments based on cytokine patterns in various BD subtypes.
Article Synopsis
- If a person has a small lesion (growth) in their body that's less than 3 cm and they don't have any symptoms, it's usually okay to just keep an eye on it.
- Many times, these small lesions don’t cause any problems and can heal on their own.
- So, doctors often recommend watching the lesion to see if it changes instead of doing surgery right away.
Objectives: Recurrent monoarthritis (RM) is a major challenge of many rheumatic diseases. Ablation is a well-known technique in the treatment of benign or malign lesions of different etiologies. We aimed to to investigate the success and safety of microwave ablation (MWA) as an adjunctive therapy in a cohort of medical treatment-resistant RM.
View Article and Find Full Text PDFThe accruing evidence about the efficacy of anti-IL-1 agents in Familial Mediterranean Fever (FMF) patients led to their widespread off-label use. Therefore, identifying precise indications and clinical characteristics of IL-1i-warranting patients are important. This study investigated the clinical characteristics and treatment indications of patients with FMF requiring interleukin 1 inhibition therapy (IL-1i).
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- The condition known as pseudo-pseudo Meigs' syndrome (PPMS) occurs in systemic lupus erythematosus (SLE) patients and is characterized by ascites, pleural effusion, and elevated CA-125 levels without any ovarian cancer.
- A 33-year-old female patient was diagnosed with SLE after experiencing persistent pleural effusion and new onset massive ascites alongside increased CA-125 levels, which led to a renal biopsy revealing class-V lupus nephritis.
- Treatment with immunosuppressants resulted in significant improvement of SLE symptoms and PPMS components, including the ascites and pleural effusion, without the necessity for diuretics, highlighting the importance of thorough evaluation and treatment in such
Article Synopsis
- A study examined cancer rates in patients with ANCA-associated vasculitis (AAV) by comparing them to cancer risks in the Turkish population and identifying independent risk factors.
- Of the 461 AAV patients tracked, 19 developed cancer after an average follow-up of about 3.4 years, with higher cancer risks noted in older males and those with anti-PR3-ANCA positivity.
- The overall cancer risk for AAV patients was 2.1 times higher than that of the general population, highlighting the need for targeted cancer screening, especially for lung and head-neck cancers in older male patients.
Protracted febrile myalgia syndrome (PFMS) is a rare form of familial Mediterranean fever (FMF) characterised by prolonged myalgia. The duration of PFMS is much longer than a typical 2-5-day attack familial Mediterranean fever and lasts for 2-6 weeks until they treated with corticosteroids. Colchicine is not effective for control of PFMS's attacks.
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- Rheumatoid arthritis (RA) is a long-lasting disease that causes joint pain and problems moving, especially in bigger joints like shoulders.
- In severe cases, treatments like medications and surgery don’t always work, leading to very limited movement and pain.
- A new treatment called microwave ablation (MWA) has shown success, helping a patient relieve pain and improve movement without serious risks.
Article Synopsis
- This study evaluated the presence of hepatitis B (HBV) and C (HCV) in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) undergoing biological treatments, using data from a registry in Türkiye.
- The findings revealed high screening rates for HBV (97% in RA and 94.2% in SpA), with varying rates of positive test results for HBV and HCV; older patients with comorbidities were more likely to test positive for HBV.
- The most commonly prescribed biologic treatments included adalimumab and etanercept, with one reported case of HBV reactivation in a patient treated with rituximab and preventative medicine.
Article Synopsis
- * Researchers analyzed data from 330 patients diagnosed with GCA, finding that 18.8% experienced relapses during a follow-up period, and only 23.8% were able to stop GC treatment entirely.
- * The study highlighted that a significant portion of patients (66.2%) had at least one indication of damage due to vasculitis, and there were also considerable side effects related to GC treatment.
Article Synopsis
- The study used the CART algorithm to analyze treatment protocols and factors affecting oral ulcers in Behçet's syndrome patients across multiple countries.
- Among 979 patients, findings revealed that those with irregular tooth brushing habits showed a higher usage of immunosuppressive (IS) medications, especially in males with major organ involvement.
- The study emphasizes the importance of promoting better oral hygiene as part of treatment strategies for patients with Behçet's syndrome.
Article Synopsis
- The study looked at how well a medication called tocilizumab (TCZ) works for people with rheumatoid arthritis (RA) who didn't respond well to other treatments.
- Researchers collected data from 258 patients using a special online registry in Turkey to track their health and any side effects.
- TCZ showed good results, with over 80% of patients still using it after a year, and it helped reduce their disease symptoms safely.
Cardiac involvement (CI) is rare in Behçet syndrome (BS), but the important point is that CI may be the first manifestation of the disease. The presence of CI worsens the prognosis of BS, so early diagnosis and early initiation of immunosuppressive treatment (IST) are vital. Coronary aneurysm may develop spontaneously in these patients, or any vascular intervention may cause aneurysm with a pathergy-like reaction.
View Article and Find Full Text PDFBehcet's syndrome is a variable vessel vasculitis characterized by recurrent oral and genital ulcers with concomitant skin, ocular, neurologic, gastrointestinal, and joint involvement. Herein, we present a patient who was diagnosed with Behcet's syndrome, which with magnetic resonance angiography showed occlusion of the right subclavian artery at the level of the thoracic outlet and reverse flow in the right vertebral artery consistent with subclavian steal syndrome. In addition, partial narrowing was noted in the left renal artery.
View Article and Find Full Text PDFObjectives: Digital ulcers (DUs) are associated with a significant burden in systemic sclerosis (SSc) by leading to severe pain, physical disability, and reduced quality of life. This effort aimed to develop recommendations of the Turkish Society for Rheumatology (TRD) on the management of DUs associated with SSc.
Methods: In the first meeting held in December 2020 with the participation of a task force consisting of 23 rheumatologists the scope of the recommendations and research questions were determined.
Article Synopsis
- A study was conducted to investigate the characteristics and outcomes of ANCA-associated vasculitis (AAV) caused by anti-thyroid drugs (ATDs), specifically focusing on microscopic polyangiitis (MPA).
- The research included 45 patients with ATD-induced AAV, and it was found that most had positive ANCA results, with skin complications and joint pain being the primary symptoms.
- Compared to primary MPA, ATD-induced MPA patients were younger, had more skin problems and fewer kidney issues, and experienced a lower risk of disease relapse after treatment.
Article Synopsis
- The study looked at how certain treatments can unexpectedly cause skin problems like paradoxical psoriasis in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA).
- Out of thousands of patients, about 136 had these unexpected skin problems, mostly after taking specific medications, and most patients were switched to new treatments to help.
- The results showed that switching medications usually worked well, and certain groups of patients, like smokers, were impacted differently by these skin reactions.
Article Synopsis
- The study assesses pulmonary issues as a significant factor in the health of patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV).
- Among 63 AAV patients, 79.4% showed pulmonary symptoms, with different CT findings linked to specific types of AAV.
- The research highlights a stronger association of severe lung involvement and interstitial lung disease with myeloperoxidase antibody (MPO)-ANCA positivity.