The Optimal Effective Dose of Adipose-Derived Stem Cell Exosomes in Wound Healing.

Introduction: Although the effect of adipose-derived mesenchymal stem cell exosomes (ADSC-exos) on wound healing with different doses are shown in various studies, efficient and sufficient doses of ADSC-exos are still unknown. The study aimed to determine the optimal dose of ADSC-exos in wound healing.

Methods: The 45 Sprague-Dawley rats were randomly divided into five groups, with seven animals in each.

Management of venous flap insufficiency: the role of low molecular weight heparin in salvage.

Flap loss resulting from venous insufficiency is a difficult issue, both with pedicled or free flaps. We examined the efficiency of low molecular weight heparin administration in various forms and dressing methods in venous insufficiency. Forty-five Sprague Dawley rats were included and inferior epigastric artery perforated island flaps were obtained from the abdominal skin of the animals.

Immediate fat and nanofat-enriched fat grafting in breast reduction for scar management.

Background: Reduction mammoplasty can be successful but surgical scars may continue to be a most undesirable and unavoidable outcome. Various medical and non-invasive methods are available to minimize scar formation but as yet no methods have been discovered to eliminate them. We hypothesize that immediate fat and nanofat-enriched fat graft transfer may improve the scar quality and optimize results.

COVID-19 Era Requires Urgent Integration of Virtual Reality Simulations in Medical Education.

Description The COVID-19 pandemic continues to cause an unprecedented level of disruption across every part of the globe. This disruption detrimentally affects the field of medical education; in particular, anatomical, surgical and clinical training, all which require hands-on experience. On the other hand, the pandemic not only brings new challenges in medical education but also opportunities for testing the validity of our old education paradigms and for developing the ability to embrace a rapid pace of change in better integrating new technologies in the medical curriculum.

A Reliable Technique in the Reconstruction of Large Penoscrotal Defect: Internal Pudendal Artery Perforator Flap.

Objective: To reconstruct the defect secondary to Fournier's gangrene, which is an infection localized in the perineum and the lower abdominal region, characterized by large tissue loss following debridement. A large tissue loss caused by Fournier's gangrene brings with repair problems. The primary goal is to achieve cosmetically and functionally successful results.

Comparative Outcomes of Inferior Pedicle and Superomedial Pedicle Technique With Wise Pattern Reduction in Gigantomastic Patients.

Introduction: Although multiple pedicle and skin excision techniques exist for gigantomastic breast reduction, no consensus exists as to which method is most effective in providing an aesthetically pleasing breast, especially in the long-term period. This study aimed to compare the aesthetic and surgical outcomes between inferior pedicle and superomedial pedicle reductions, which both use Wise pattern skin excision in gigantomastic patients.

Methods: A prospective study was planned, and the number of patients was determined before the beginning of the study.

A very interesting traditional method in the treatment of skin lesions: aqua regia and related complications.

Background: Aqua regia, a highly corrosive mixture of concentrated nitric acid and hydrochloric acid, is used to dissolve various metals such as gold and platinum that are not soluble in other types of acids. For the first time in the literature, we report the adverse effects that were observed following the utilization of this strong acid solution in the treatment of various skin lesions.

Methods: Between 2010 and 2013, 43 patients (55.

A decision-making guide for the closure of myelomeningocele skin defects with or without primary repair.

OBJECTIVE The closure of the skin defect in myelomeningocele (MMC) repair is an essential step that determines the quality of the surgical result. The success of surgical results is related to the decision to use the most suitable techniques, namely flaps or primary closure. The aim of this study was to evaluate the effectiveness of a decision-making guide to determine whether to use primary repair or a flap for the closure of skin defects that occur in MMC.

Nanofat grafting under a split-thickness skin graft for problematic wound management.

Introduction: Obesity and certain medical disorders make the reconstruction of skin defects challenging. Different kind of procedure can be used for these defect, besides, skin grafting is one of the most common and simplest procedure. Fat grafting and stem cells which are located in the adipose tissue have been commonly used in plastic surgery for regeneration and rejuvenation purposes.

The alar rim flap: a novel technique to manage malpositioned lateral crura.

Background: Alar cartilage malposition is a common anatomic variation in which the axis of the lateral crus lies cephalically and may be parallel to the cephalic septum. Malposition of the lateral crura may produce inward collapse of the alae that is observable on deep inspiration.

Objectives: The authors performed the alar rim flap technique to treat patients with alar malposition and assessed functional and aesthetic outcomes.

The effect of sildenafil on fascia-wrapped diced cartilage grafts.

Objectives/hypothesis: Diced cartilage grafts are frequently used, especially in rhinoplasty. The effect of sildenafil on the viability of diced cartilage grafts was investigated in this study.

Study Design: Animal experiment.

Reconstruction of a subtotally amputated auricle with a very narrow inferior pedicle.

In our case study, the left ear of a 57-year-old male patient was subtotally amputated due to an iron-plate cutting accident. Only a 5-mm inferior skin pedicle connected the amputated ear to the lobule. The ear was reattached with primary suture without microsurgery.

A comparison of diced cartilage grafts wrapped in perichondrium versus fascia.

Unlabelled: Cartilage grafts are the most commonly used grafts for structural and aesthetic purposes. This study aimed to compare the viability of diced cartilage grafts wrapped in fascia with diced cartilage grafts wrapped in perichondrium. Approximately 2 × 2 cm cartilage grafts were harvested from the ears of seven New Zealand rabbits, diced to approximately 1-mm cubes, and then wrapped in perichondrium harvested from the ears or muscle fascia harvested from the right rear leg of the same rabbits.

An unpredicted side effect of prophylactic antibiotic use.

Introduction And Objective: We investigated the effects of cefazolin sodium (CS), on wound healing in rats.

Material And Method: Forty rats in which an incisional wound model was created by removing two skin strips (4×1 cm), and suturing the wound edges, were included. Four groups were formed in a randomized way with each having 10 rats.