Evaluation of significant gene expression changes in congenital and acquired cholesteatoma.

Etiopathogenesis of acquired and congenital cholesteatoma is still unclear. The clinical behavior of adult acquired, pediatric acquired and congenital cholesteatomas show differences. The scope of the this study was to detect the matrix metalloproteinase (MMP), tissue inhibitors of metalloproteinase (TIMP) and epidermal growth factor receptor (EGFR) gene expression changes in cholesteatoma perimatrix and to compare these changes among congenital cholesteatoma, adult acquired cholesteatoma and pediatric acquired cholesteatoma.

Reliability and validity of the Turkish version of the Vocal Fatigue Index.

Background/aim: The aim of this study is to evaluate the reliability and validity of the Turkish version of the Vocal Fatigue Index (VFI).

Materials And Methods: The study was conducted with 535 participants including 285 patients with voice disorders and 250 healthy controls. Internal consistency and test-retest reliability were calculated for the reliability analysis.

Cisplatin ototoxicity in children: risk factors and its relationship with polymorphisms of DNA repair genes ERCC1, ERCC2, and XRCC1.

Purpose: We aimed to investigate the cisplatin-related hearing toxicity and its possible relationship with polymorphic variants in DNA repair genes, ERCC1, ERCC2, and XRCC1.

Methods: Fifty patients treated with cisplatin in the past were included in the study. There were 29 females and 21 males; mean age 13.

Comparison of anterior and posterior tympanomeatal flap elevations in endoscopic transcanal tympanoplasty.

There is not an ideal tympanomeatal flap incision type for transcanal procedures. Comparing the outcomes and feasibility of posteriorly and anteriorly based tympanomeatal flap incisions for anterior perforations in endoscopic transcanal cartilage tympanoplasty. Twenty-six patients who had anterior TM perforation were included.

Malignant Otitis Externa: A Retrospective Analysis and Treatment Outcomes.

Objective: The purpose of this study was to analyze previous treatments and outcomes in patients with malignant otitis externa (MOE) retrospectively. The efficacy of medical and surgical treatments was also evaluated.

Methods: This study included 25 patients diagnosed with MOE and treated at the Department of Otorhinolaryngology, Ege University School of Medicine between 2006 and 2017.

The Effect of Endoscopic Tympanoplasty on Cochlear Function.

Objectives: The aim of this prospective clinical study was to measure the audiologic outcomes of the patients that underwent endoscopic transcanal cartilage tympanoplasty, and to investigate the effects on cochlear function.

Methods: Thirty-three patients (33 ears) who were diagnosed with noncomplicated chronic otitis media and underwent endoscopic transcanal cartilage tympanoplasty technique were included. Pre- and postoperative first month distortion product otoacoustic emission (DPOAE) signal-to-noise ratio (SNR), bone conduction hearing levels and air bone gap (ABG) values were measured and total endoscope usage time was noted.

Pediatric type 1 cartilage tympanoplasty outcomes: A comparison of short and long term hearing results.

Objective: Tympanoplasty is a commonly used procedure in children as in adults. The purposes of this study were to evaluate and report the long term results of type 1 cartilage tympanoplasty in pediatric population. Short term and long term hearing outcomes were compared according to age and perforation location.

Clinical and video head impulse test in the diagnosis of posterior circulation stroke presenting as acute vestibular syndrome in the emergency department.

Introduction: Head impulse test (HIT) is the critical bedside examination which differentiates vestibular neuritis (VN) from posterior circulation stroke (PCS) in acute vestibular syndrome (AVS). Video-oculography based HIT (vHIT) may have aadditional strength in making the differentiation.

Methods: Patients admitted to the emergency department of a tertiary-care medical center with AVS were studied.

Butterfly Cartilage Tympanoplasty Long-term Results: Excellent Treatment Method in Small and Medium Sized Perforations.

Objectives: The aim of this study was to evaluate and report the long-term results of the butterfly cartilage tympanoplasty. Short-term and long-term hearing outcomes were compared according to age and perforation location as well.

Methods: Ninety-three patients who were diagnosed with noncomplicated chronic otitis media and underwent microscopic transcanal butterfly cartilage tympanoplasty due to anterior, posterior, and central tympanic membrane perforation were included.

Results of endoscopic cartilage tympanoplasty procedure with limited tympanomeatal flap incision.

Objective: The aim of this study was to evaluate the outcomes of this minimally invasive tympanomeatal incision technique performed during endoscopic transcanal cartilage tympanoplasty.

Study Design: Prospective clinical study.

Methods: Eighty-seven patients (87 ears) who had TM perforation with noncomplicated COM were included.

Endoscopic versus microscopic type 1 tympanoplasty in the same patients: a prospective randomized controlled trial.

The aim of this study was to compare the audiologic outcomes of the patients who underwent endoscopy on one ear and microscopic tympanoplasty on the other, and to investigate the operative time, graft success, postoperative pain and health status. This prospective randomized controlled study was carried out in Ege University ENT Department between February 2015 and September 2016. The patients who had bilateral chronic otitis media, normal middle ear mucosa and a hearing loss difference of 10 dB or less between the two ears randomly underwent microscopic tympanoplasty in one ear and endoscopic tympanoplasty in the contralateral ear, with 6-month intervals.

Butterfly cartilage tympanoplasty: an alternative new technique instead of conventional surgery method.

Butterfly graft inlay tympanoplasty is a well-established technique for the repair of small- and medium-sized perforations. There are some difficulties with application of conventional butterfly technique and it affects our success rate of graft healing. With some modifications of graft preparation we can make better success rates.

Turkish validity and reliability of Eustachian tube dysfunction questionnaire-7.

Introduction: During clinical evaluations, in order to interpret patients' complaints caused by Eustachian tube dysfunction and to monitor the success of the treatment, standardized and disease-related scales are necessary.

Objective: The aim of this study was to investigate the validity and reliability of the Turkish version of Eustachian tube dysfunction questionnaire-7.

Methods: Forty patients diagnosed with Eustachian tube dysfunction and 40 healthy individuals were enrolled for the study.

The Effect of Mandibulectomy and Mandibulotomy on Cochlear Function.

Mandibulectomy and mandibulotomy procedures are performed with the oscillating saw and the acoustic energy generated during the osteotomies is transferred to the cochlea via temporomandibular joint and air conduction. The aim of this study was to assess the effect of mandibulectomy and mandibulotomy on cochlear function. This study was carried out on 15 patients who underwent at an otolaryngology department of a tertiary medical center between January 2013 and August 2015.

Revisiting the Anatomy of the Facial Recess: The Boundaries of the Round Window Exposure.

Background: The exposure of the round window (RW) through the facial recess (FR) is sometimes partial. The anatomic variations that alter RW exposure during cochleostomy have not been clearly defined to date.

Aims: The aim of this study was to assess the best FR position in which to achieve the widest exposure of the RW niche and to define the topographic relationship between two other important anatomical structures, the facial nerve (FN) and the chorda tympani (CT).

Establishing a "Vestibular Migraine Diagnosis Questionnaire" and Testing Its Validity.

Objective: To establish a questionnaire and check its validity and reliability for the diagnosis of vestibular migraine in patients reporting recurrent vestibular symptoms.

Background: Vestibular migraine is the most common cause for recurrent spontaneous vertigo. However, it is still underdiagnosed needing validated and reliable screening instruments such as ID Migraine, that can be used in primary care settings, dizziness, and migraine clinics.

Acetazolamide in vestibular migraine prophylaxis: a retrospective study.

The aim of this study is to check the efficacy of acetazolamide in the prophylaxis of vestibular migraine (VM). Treatment options in VM are mainly based on migraine guidelines. We tried to assess the efficacy of acetazolamide in these patients depending on clinical similarities with episodic ataxia type 2 and familial hemiplegic migraine responding to the drug.

Establishment and reliability test of a "Vertigo Council Diagnosis Questionnaire" for patients with chronic vestibular dysfunction: preliminary study.

Objectives: This study aims to establish a "Vertigo Council Diagnosis Questionnaire" for patients with chronic vestibular dysfunction and show the reliability of this questionnaire.

Materials And Methods: A "Vertigo Council Diagnosis Questionnaire" consisting of 10 questions was prepared by 15 specialist physicians and analyzed for reliability using the "translation-back-translation" method.

Results: When all the items of our questionnaire were evaluated, the content validity ratio ranged from 0.

General approach to the treatment of odontogenic abscesses and cost analysis.

Purpose: The purpose of this study was to evaluate the relationships between age, gender, symptoms, treatment, length of hospital stay and hospital cost in a group of patients with severe odontogenic infection who has been admitted within the last 6 years.

Subjects And Methods: This study was carried out on 30 patients who had been treated in Ege University, Faculty of Medicine, Otolaryngology Department with the diagnosis of odontogenic abscess. Variables such as age, gender, symptoms, systemic disease, imaging techniques, treatment modalities, hospital length of stay and hospital cost were analyzed statistically.

Lemierre's Syndrome Case Secondary to Otitis Media.

Lemierre's syndrome is a rare but fatal thrombophlebitis of the internal jugular vein (IJV). It usually follows acute oropharyngeal infections in healthy, young adults. Fusobacterium necrophorum is the most common bacteria that causes Lemierre's syndrome, whereas various microorganisms are reported.